Jak2 Gene Summary [Mouse]
Enables interleukin-12 receptor binding activity; non-membrane spanning protein tyrosine kinase activity; and signaling receptor activator activity. Involved in several processes, including cell surface receptor signaling pathway; hemopoiesis; and positive regulation of metabolic process. Acts upstream of or within several processes, including cell surface receptor signaling pathway; cellular response to dexamethasone stimulus; and regulation of apoptotic process. Located in caveola and nucleus. Is active in cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver and biliary system; and musculoskeletal system. Used to study essential thrombocythemia; myelofibrosis; myeloproliferative neoplasm; and polycythemia vera. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); hematologic cancer (multiple); hepatic vascular disease (multiple); inflammatory bowel disease (multiple); and lung non-small cell carcinoma (multiple). Orthologous to human JAK2 (Janus kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Jak2 |
| Official Name | Janus kinase 2 [Source:MGI Symbol;Acc:MGI:96629] |
| Ensembl ID | ENSMUSG00000024789 |
| Bio databases IDs | |
| Aliases | Janus kinase 2 |
| Synonyms | AI504024, C81284, Fd17, Janus kinase 2, JTK10 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Jak2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase
- ATP-binding domain
- Jak Homology domain
- receptor activator
- G-protein-coupled receptor binding
- enzyme
- protein-tyrosine kinase
- Protein kinase domain
- identical protein binding
- activation loop
- YMIM motif
- FERM domain
- cytoplasmic domain
- Src homology 2 (SH2) domain
- FERM domain B-lobe
- Tyrosine kinase, catalytic domain
- Band 4.1 homologues
- histone binding
- Protein kinase (unclassified specificity)
- protein kinase binding
- JH2 domain
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- SH2-domain binding
- YxxL motif
- kinase-like domain
- non-membrane spanning protein tyrosine kinase
- FERM F1 ubiquitin-like domain
- protein binding
- receptor binding
- heme binding
- Pleckstrin homology-like domain
- autophosphorylation site
- pseudo kinase domain
- phosphorylation site
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- phosphoinositide 3-kinase binding
- Protein Kinases, catalytic domain
- interleukin-12 receptor binding
- Jak1 pleckstrin homology-like domain
- tyrosine kinase domain
- growth hormone receptor binding
Pathways
Biological processes and signaling networks where the Jak2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Ephrin A Signaling
- Glucocorticoid Receptor Signaling
- GM-CSF Signaling
- Growth Hormone Signaling
- IGF-1 Signaling
- IL-15 Production
- IL-6 Signaling
- iNOS Signaling
- Interferon Signaling
- JAK/Stat Signaling
- Leptin Signaling in Obesity
- MSP-RON Signaling Pathway
- Oncostatin M Signaling
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Role of JAK1, JAK2 and TYK2 in Interferon Signaling
- Role of JAK2 in Hormone-like Cytokine Signaling
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Tissue Factor in Cancer
- SPINK1 General Cancer Pathway
- Th1 Pathway
- Th2 Pathway
- TREM1 Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- esophageal squamous cell carcinoma
- advanced non-small cell lung cancer
- non-small cell lung cancer
- metastatic non-small cell lung cancer
- advanced lung squamous cell carcinoma
- epithelial cancer
- cancer
- pancreatic cancer
- stage IV lung squamous cell carcinoma
role in cell
- expression in
- production in
- apoptosis
- cell viability
- activation in
- proliferation
- migration
- stabilization in
- cell death
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- raft fractions
- caveolae fraction
- low-density microsomal fraction
- membrane fraction
- glutaminergic synapse
- cell surface
- perinuclear region
- postsynaptic region
- focal adhesions
- Nucleus
- Plasma Membrane
- endosomes
- Endoplasmic Reticulum
- cytoplasmic matrix
- cytosol
- cytoplasmic face of plasma membrane
- caveolar membranes
- caveolae
- nucleoplasm
- nuclear matrix
- neuromuscular junctions
- cytoplasmic vesicles
- membrane rafts
- chromatin
- euchromatin compartments
- dendrites
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Jak2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- activation of Janus kinase activity
- peptidyl-tyrosine phosphorylation
- post-embryonic hemopoiesis
- granulocyte-macrophage colony-stimulating factor signaling pathway
- interleukin-3-mediated signaling pathway
- negative regulation of cell-cell adhesion
- mesoderm development
- protein autophosphorylation
- transcription from RNA polymerase II promoter
- positive regulation of tyrosine phosphorylation of STAT protein
- activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
- JAK-STAT cascade
- positive regulation of T-helper 17 type immune response
- negative regulation of DNA binding
- immune response
- mineralocorticoid receptor signaling pathway
- positive regulation of interferon-gamma production
- apoptotic process
- mammary gland epithelium development
- positive regulation of cell-substrate adhesion
- positive regulation of tumor necrosis factor production
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- intracellular signal transduction
- growth hormone receptor signaling pathway
- tyrosine phosphorylation of STAT protein
- JAK-STAT cascade involved in growth hormone signaling pathway
- positive regulation of protein import into nucleus
- positive regulation of growth hormone receptor signaling pathway
- G-protein coupled receptor signaling pathway
- collagen-activated signaling pathway
- response to amine stimulus
- platelet-derived growth factor receptor signaling pathway
- adaptive immune response
- induction of apoptosis by oxidative stress
- regulation of JAK-STAT cascade
- regulation of apoptotic process
- positive regulation of T cell proliferation
- positive regulation of JAK-STAT cascade
- tumor necrosis factor-mediated signaling pathway
- erythrocyte differentiation
- positive regulation of nitric-oxide synthase biosynthetic process
- response to interleukin-12
- regulation of synaptic transmission
- regulation of inflammatory response
- negative regulation of cardiac muscle cell apoptotic process
- interleukin-35-mediated signaling pathway
- axon regeneration
- positive regulation of protein kinase B signaling cascade
- response to tumor necrosis factor
- positive regulation of cell migration
- positive regulation of nitric oxide biosynthetic process
- host programmed cell death induced by symbiont
- negative regulation of cell proliferation
- extrinsic apoptotic signaling pathway
- response to antibiotic
- protein phosphorylation
- positive regulation of transcription from RNA polymerase II promoter
- regulation of nitric oxide biosynthetic process
- post-translational protein modification
- positive regulation of MHC class II biosynthetic process
- negative regulation of neuron apoptotic process
- chromatin remodeling
- cytokine-mediated signaling pathway
- positive regulation of NK T cell proliferation
- positive regulation of leukocyte proliferation
- positive regulation of interleukin-17 production
- interleukin-6-mediated signaling pathway
- positive regulation of SMAD protein import into nucleus
- positive regulation of insulin secretion
- response to hydroperoxide
- positive regulation of platelet activation
- interferon-gamma-mediated signaling pathway
- signal transduction
- positive regulation of receptor activity
- interleukin-5-mediated signaling pathway
- actin filament polymerization
- positive regulation of cell differentiation
- positive regulation of MAPK cascade
- enzyme linked receptor protein signaling pathway
- elevation of cytosolic calcium ion concentration
- microglial cell activation
- cellular response to lipopolysaccharide
- positive regulation of natural killer cell proliferation
- cell differentiation
- response to lipopolysaccharide
- cellular response to interleukin-3
- cellular response to dexamethasone stimulus
- positive regulation of interleukin-1 beta production
- interleukin-12-mediated signaling pathway
- positive regulation of apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- interleukin-12 receptor complex
- plasma membrane
- nucleoplasm
- nucleus
- caveola
- euchromatin
- granulocyte macrophage colony-stimulating factor receptor complex
- cytoskeleton
- focal adhesion
- cytoplasm
- membrane raft
- endosome lumen
- interleukin-23 receptor complex
- extrinsic to internal side of plasma membrane
- cytosol
- extrinsic to plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol 3-kinase binding
- protein kinase binding
- identical protein binding
- acetylcholine receptor binding
- interleukin-12 receptor binding
- growth hormone receptor binding
- protein kinase activity
- SH2 domain binding
- receptor binding
- heme binding
- ATP binding
- protein tyrosine kinase activity
- protein binding
- type 1 angiotensin receptor binding
- non-membrane spanning protein tyrosine kinase activity
- histone binding
- metal ion binding
- insulin receptor substrate binding
- peptide hormone receptor binding
- histone kinase activity (H3-Y41 specific)