Il4ra Gene Summary [Mouse]
Predicted to enable interleukin-4 receptor activity. Involved in positive regulation of chemokine production; positive regulation of cold-induced thermogenesis; and positive regulation of macrophage activation. Acts upstream of or within several processes, including defense response to protozoan; negative regulation of T-helper 1 cell differentiation; and positive regulation of immune effector process. Predicted to be located in centriolar satellite; extracellular space; and nucleoplasm. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including adrenal medulla; early conceptus; hemolymphoid system; medulla oblongata basal plate mantle layer; and reproductive system. Used to study asthma. Human ortholog(s) of this gene implicated in several diseases, including acne; allergic conjunctivitis; multiple sclerosis (multiple); renal tuberculosis; and rheumatoid arthritis. Orthologous to human IL4R (interleukin 4 receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il4ra |
| Official Name | interleukin 4 receptor, alpha [Source:MGI Symbol;Acc:MGI:105367] |
| Ensembl ID | ENSMUSG00000030748 |
| Bio databases IDs | |
| Aliases | interleukin 4 receptor, alpha |
| Synonyms | CD124, IL-4RA, IL4R alpha, Il4r beta, IL-4 receptor, il 4 receptor α chain, IL-4R-α, Il4r β, interleukin 4 receptor, interleukin 4 receptor, alpha, interleukin 4 receptor, α, MFF receptor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Il4ra often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- interleukin-4 receptor
- ectodomain
- Interleukin-4 receptor alpha chain, N-terminal
- NPXF motif
- protein binding
- Fibronectin type 3 domain
- acidic domain
- membrane distal domain
- docking domain
- ID-1 domain
- binding protein
- serine-rich region
- cytoplasmic domain
- immunoreceptor tyrosine-based inhibition motif
- FN3
- intracellular domain
- Insulin/Il4 receptor motif
- cytosolic tail domain
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Il4ra gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- metastasis
- advanced cancer
- cancer
- neoplasia
- hyperactive behavior
- hyperplasia
- endometriosis
- atopic dermatitis
- sinonasal polyposis
role in cell
- expression in
- proliferation
- activation in
- binding
- phosphorylation in
- function
- apoptosis
- activation
- production in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Extracellular Space
- cellular membrane
- centrosome
- apical cell surfaces
- nucleoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Il4ra gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of mast cell degranulation
- interleukin-4-mediated signaling pathway
- signal transduction
- positive regulation of T-helper 2 cell differentiation
- negative regulation of T-helper 1 cell differentiation
- defense response to protozoan
- T-helper 1 cell differentiation
- production of molecular mediator involved in inflammatory response
- T-helper 2 cell differentiation
- immune response
- cytokine-mediated signaling pathway
- positive regulation of macrophage activation
- immunoglobulin mediated immune response
- positive regulation of immunoglobulin production
- positive regulation of chemokine production
Cellular Component
Where in the cell the gene product is active
- centriolar satellite
- external side of plasma membrane
- receptor complex
- extracellular region
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- interleukin-4 receptor activity
- cytokine receptor activity