Il5 Gene Summary [Mouse]
Enables cytokine activity. Involved in positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; and positive regulation of immunoglobulin production. Acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation. Located in extracellular space. Is expressed in colon; thymus; and thymus primordium. Human ortholog(s) of this gene implicated in asthma and stomach cancer. Orthologous to human IL5 (interleukin 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il5 |
| Official Name | interleukin 5 [Source:MGI Symbol;Acc:MGI:96557] |
| Ensembl ID | ENSMUSG00000036117 |
| Bio databases IDs | |
| Aliases | interleukin 5 |
| Synonyms | EDF, interleukin 5, TRF |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Il5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- interleukin-5 receptor binding
- Interleukin 5
- protein binding
- cytokine
Pathways
Biological processes and signaling networks where the Il5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Airway Inflammation in Asthma
- Allograft Rejection Signaling
- Autoimmune Thyroid Disease Signaling
- Communication between Innate and Adaptive Immune Cells
- Erythropoietin Signaling
- Fc Epsilon RI Signaling
- Glucocorticoid Receptor Signaling
- Hematopoiesis from Multipotent Stem Cells
- Hematopoiesis from Pluripotent Stem Cells
- Hepatic Cholestasis
- HMGB1 Signaling
- IL-17 Signaling
- RAR Activation
- Role of Cytokines in Mediating Communication between Immune Cells
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- T Cell Receptor Signaling
- T Helper Cell Differentiation
- Th1 and Th2 Activation Pathway
- Th2 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- edema
- chronic obstructive pulmonary disease
- colitis
- asthma
- chronic rhinosinusitis with nasal polyps
- metastasis
- severe pulmonary eosinophilia
- eosinophilia
- Churg-Strauss syndrome
role in cell
- activation
- expression in
- activation in
- phosphorylation in
- production in
- quantity
- formation
- binding in
- adhesion
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- Plasma Membrane
- granule matrix
- secretory granules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Il5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- immune response
- interleukin-5-mediated signaling pathway
- positive regulation of transcription, DNA-dependent
- positive regulation of immunoglobulin production
- positive regulation of B cell proliferation
- positive regulation of podosome assembly
- positive regulation of peptidyl-tyrosine phosphorylation
- positive regulation of eosinophil differentiation
- positive regulation of JAK-STAT cascade
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- cytokine activity
- interleukin-5 receptor binding