TFCP2 Gene Summary [Human]
This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded protein regulates erythroid gene expression, plays a role in the transcriptional switch of globin gene promoters, and it activates many other cellular and viral gene promoters. The gene product interacts with certain inflammatory response factors, and polymorphisms of this gene may be involved in the pathogenesis of Alzheimer's disease. [provided by RefSeq, Mar 2010]
Details
| Type | Protein Coding |
| Official Symbol | TFCP2 |
| Official Name | transcription factor CP2 [Source:HGNC Symbol;Acc:HGNC:11748] |
| Ensembl ID | ENSG00000135457 |
| Bio databases IDs | |
| Aliases | transcription factor CP2 |
| Synonyms | alpha CP2, Alpha-globin transcription factor cp2, CP-2, CP2c, D230015P20RIK, LBP1, LBP-1c, LBP-1d, LSF, LSF1D, SEF, Tcfcp2, TFCP2C, transcription factor CP2, UBP-1, α CP2, α-globin transcription factor cp2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TFCP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- dimerization domain
- DNA binding domain
- nucleic acid binding
- Q/P domain
- SAM (Sterile alpha motif )
- C-terminal acidic domain
- transcription factor binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- SAM domain (Sterile alpha motif)
- SPXX domain
- extreme N-terminal domain
- SAM like-domain
- basic domain
- transcription factor activity
- CP2 transcription factor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- hepatocellular carcinoma
- tumorigenesis
- epithelial cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- liver cancer
- Alzheimer disease
- psoriasis
role in cell
- expression in
- cell death
- activation in
- cell cycle progression
- growth
- apoptosis
- proliferation
- formation
- formation in
- upregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytosol
- nucleoplasm
- chromatin
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TFCP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- macromolecular complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- transcription factor binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity