MAP2K5 Gene Summary [Human]
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011]
Details
| Type | Protein Coding |
| Official Symbol | MAP2K5 |
| Official Name | mitogen-activated protein kinase kinase 5 [Source:HGNC Symbol;Acc:HGNC:6845] |
| Ensembl ID | ENSG00000137764 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase kinase 5 |
| Synonyms | HsT17454, MAP kinase kinase 5, MAPKK5, MEK5, mitogen-activated protein kinase kinase 5, MKK5, PRKMK5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAP2K5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein threonine/tyrosine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- ATP-binding domain
- Protein tyrosine and serine/threonine kinase
- ATP binding
- aPKC binding domain
- protein binding
- Protein kinase domain
- PB1
- Phox and Bem1 domain
- kinase
- MAP kinase kinase
- Serine/Threonine protein kinases, catalytic domain
- acidic cluster
- Protein Kinases, catalytic domain
- MAP kinase
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the MAP2K5 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Acute Myeloid Leukemia Signaling
- BER pathway
- CD27 Signaling in Lymphocytes
- CD40 Signaling
- Cholecystokinin/Gastrin-mediated Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endocannabinoid Developing Neuron Pathway
- ERK5 Signaling
- HIF1α Signaling
- HMGB1 Signaling
- Human Embryonic Stem Cell Pluripotency
- IL-15 Production
- Melatonin Signaling
- Neurotrophin/TRK Signaling
- NRF2-mediated Oxidative Stress Response
- Nur77 Signaling in T Lymphocytes
- Polyamine Regulation in Colon Cancer
- Reelin Signaling in Neurons
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Tissue Factor in Cancer
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- movement disorder
- psoriasis
- restless legs syndrome
- pervasive developmental disorder
- metabolic syndrome X
- non-insulin-dependent diabetes mellitus
- reperfusion injury
- obesity
- posterior cortical atrophy
role in cell
- expression in
- apoptosis
- phosphorylation in
- cell death
- activation in
- cell viability
- assembly
- quantity
- proliferation
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent-insoluble fractions
- spindle apparatus
- perinuclear region
- cytosol
- detergent-soluble fraction
- cytoskeletal fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAP2K5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- negative regulation of smooth muscle cell apoptotic process
- negative regulation of response to cytokine stimulus
- signal transduction
- negative regulation of NF-kappaB transcription factor activity
- insulin-like growth factor receptor signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of cell migration involved in sprouting angiogenesis
- negative regulation of transcription from RNA polymerase II promoter
- heart development
- positive regulation of protein metabolic process
- MAPK cascade
- positive regulation of cell growth
- ERK5 cascade
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- negative regulation of interleukin-8 production
- cellular response to growth factor stimulus
- negative regulation of heterotypic cell-cell adhesion
- cellular response to laminar fluid shear stress
- negative regulation of chemokine (C-X-C motif) ligand 2 production
- positive regulation of epithelial cell proliferation
Cellular Component
Where in the cell the gene product is active
- spindle
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- protein binding
- metal ion binding
- MAP kinase kinase activity
- protein kinase activity
- protein serine/threonine kinase activity