PRKACB Gene Summary [Human]
The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2014]
Details
| Type | Protein Coding |
| Official Symbol | PRKACB |
| Official Name | protein kinase cAMP-activated catalytic subunit beta [Source:HGNC Symbol;Acc:HGNC:9381] |
| Ensembl ID | ENSG00000142875 |
| Bio databases IDs | |
| Aliases | protein kinase cAMP-activated catalytic subunit beta |
| Synonyms | beta-CATALYTIC subunit of PKA, CAFD2, Cat Beta, Cat β, CbPKA, PKACB, PKA C-beta, PKA C-β, Prkacb predicted, protein kinase cAMP-activated catalytic subunit beta, protein kinase cAMP-activated catalytic subunit β, protein kinase, cAMP dependent, catalytic, beta, protein kinase, cAMP dependent, catalytic, β, β-CATALYTIC subunit of PKA |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRKACB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- protein serine/threonine kinase
- cAMP-dependent protein kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein tyrosine and serine/threonine kinase
- ATP binding
- protein binding
- magnesium ion binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Extension to Ser/Thr-type protein kinases
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the PRKACB gene in human plays a role, providing insight into its function and relevance in health or disease.
- Amyloid Processing
- Apelin Adipocyte Signaling Pathway
- Apelin Pancreas Signaling Pathway
- BMP signaling pathway
- Calcium Signaling
- CDK5 Signaling
- Corticotropin Releasing Hormone Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Dopamine Receptor Signaling
- Endocannabinoid Developing Neuron Pathway
- eNOS Signaling
- Ephrin A Signaling
- Glucocorticoid Receptor Signaling
- Gαi Signaling
- IL-1 Signaling
- Leptin Signaling in Obesity
- Melanocyte Development and Pigmentation Signaling
- Myc Mediated Apoptosis Signaling
- Netrin Signaling
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- NF-κB Signaling
- P2Y Purinergic Receptor Signaling Pathway
- Phototransduction Pathway
- PXR/RXR Activation
- Sonic Hedgehog Signaling
- Tight Junction Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumorigenesis
- Alzheimer disease
- dry eye syndrome
- epithelial cancer
- septic shock
- type II collagen-induced arthritis
- acinar-cell carcinoma
- neoplastic cell transformation
- cardioacrofacial dysplasia type 2
- breast carcinoma
role in cell
- phosphorylation in
- transactivation in
- apoptosis
- proliferation
- survival
- transformation
- quantity
- assembly
- potentiation
- specification
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- perinuclear region
- Nucleus
- centrosome
- cytosol
- nucleoplasm
- neurites
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRKACB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- high-density lipoprotein particle assembly
- renal water homeostasis
- neural tube closure
- signal transduction
- protein kinase A signaling cascade
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- protein phosphorylation
- negative regulation of smoothened signaling pathway
- regulation of protein processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- extracellular vesicular exosome
- cytosol
- plasma membrane
- cAMP-dependent protein kinase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- ubiquitin protein ligase binding
- AMP-activated protein kinase activity
- protein binding
- cAMP-dependent protein kinase activity
- protein serine/threonine kinase activity