Cxcl10 Gene Summary [Mouse]
Predicted to enable chemoattractant activity; chemokine receptor binding activity; and heparin binding activity. Involved in cellular response to interleukin-17. Acts upstream of or within several processes, including defense response to virus; negative regulation of myoblast differentiation; and negative regulation of myoblast fusion. Located in external side of plasma membrane and extracellular space. Is expressed in several structures, including alimentary system; axial skeleton; hemolymphoid system; lacrimal gland; and liver. Human ortholog(s) of this gene implicated in hepatitis B; middle cerebral artery infarction; and type 1 diabetes mellitus. Orthologous to human CXCL10 (C-X-C motif chemokine ligand 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Cxcl10 |
| Official Name | chemokine (C-X-C motif) ligand 10 [Source:MGI Symbol;Acc:MGI:1352450] |
| Ensembl ID | ENSMUSG00000034855 |
| Bio databases IDs | |
| Aliases | chemokine (C-X-C motif) ligand 10 |
| Synonyms | C7, CRG-2, C-X-C motif chemokine ligand 10, gIP-10, Ifi10, INP10, IP-10, mob-1, Scyb10 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cxcl10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chemokine
- chemoattractant
- Small cytokines (intecrine/chemokine), interleukin-8 like
- CXCR3 chemokine receptor binding
- cytokine
- heparin binding
Pathways
Biological processes and signaling networks where the Cxcl10 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- insulin-dependent diabetes mellitus
- Huntington disease
- delayed hypersensitive reaction
- multiorgan inflammation
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- demyelination
- dilated cardiomyopathy
phenotypes
- CNS inflammation
- abnormal T cell physiology
- abnormal cytokine secretion
- abnormal interferon level
- decreased CD8-positive alpha-beta T cell number
- decreased IgG2a level
- decreased interferon-gamma secretion
- decreased splenocyte proliferation
- decreased susceptibility to type IV hypersensitivity reaction
- demyelination
- increased susceptibility to Hepadnaviridae infection
- increased susceptibility to Herpesvirales infection
- increased susceptibility to experimental autoimmune encephalomyelitis
role in cell
- cell viability
- accumulation
- activation
- proliferation
- binding
- chemotaxis
- cellular infiltration by
- invasion
- differentiation
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- intracellular space
- plasma membrane extracellular face
- basal lamina
- exosomes