CD209 Gene Summary

This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including leprosy and tuberculosis mycobacteria, the Ebola, hepatitis C, HIV-1 and Dengue viruses, and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain, a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CLEC4M (Gene ID: 10332), also known as L-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression on the surface of dendritic cells. Polymorphisms in the neck region are associated with protection from HIV-1 infection, while single nucleotide polymorphisms in the promoter of this gene are associated with differing resistance and susceptibility to and severity of infectious disease, including rs4804803, which is associated with SARS severity. [provided by RefSeq, May 2020]

Details

Type
Protein Coding
Official Symbol
CD209
Official Name
CD209 molecule [Source:HGNC Symbol;Acc:HGNC:1641]
Ensembl ID
ENSG00000090659
Bio databases IDs NCBI: 30835 Ensembl: ENSG00000090659
Aliases CD209 molecule
Synonyms
Cd209a,CD209a molecule,CD209 molecule,CDSIGN,CLEC4L,DC-SIGN,DC-SIGN1,GP120 binding,hDC-SIGN,MDC-SIGN1,SDC-SIGN1
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • virion binding
  • extracellular domain
  • viral receptor
  • C-type lectin (CTL)/C-type lectin-like (CTLD) domain
  • carbohydrate recognition domain
  • tyrosine internalization motif
  • protein binding
  • mannose binding
  • internalization targeting signal
  • dileucine internalization motif
  • binding protein
  • cytoplasmic domain
  • transmembrane domain
  • Lectin C-type domain
  • cytosolic tail domain
  • neck domain

Pathways

Biological processes and signaling networks where the CD209 gene plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • infection
  • susceptibility to human immunodeficiency virus type 1
  • androgenic alopecia
  • susceptibility to tuberculosis
  • human immunodeficiency virus I infection
  • diabetic nephropathy
  • epithelial thyroid cancer
  • tuberculosis
  • anaplastic thyroid carcinoma
  • anaplastic thyroid cancer
regulated by
  • mir-10 (includes others)
  • lipopolysaccharide
  • sirolimus
  • tetradecanoylphorbol acetate
  • dexamethasone
  • IL10
  • IL6
  • TNF
  • Ca2+
  • CSF1
regulates
role in cell
  • formation
  • proliferation
  • production in
  • expression in
  • activation in
  • activation
  • migration
  • function
  • binding
  • clustering

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • raft fractions
  • Cytoplasm
  • cell surface
  • Extracellular Space
  • cellular membrane
  • plasma membrane extracellular face
  • microdomains
  • early endosomes
  • membrane rafts

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the CD209 gene, providing context for its role in the cell.

biological PROCESS

Functions and activities the gene product is involved in
  • regulation of T cell proliferation
  • viral entry into host cell
  • interspecies interaction between organisms
  • heterophilic cell-cell adhesion
  • adaptive immune response
  • positive regulation of T cell proliferation
  • endocytosis
  • cell-cell recognition
  • peptide antigen transport
  • leukocyte cell-cell adhesion
  • viral attachment to host cell
  • immune response
  • innate immune response
  • viral genome replication
  • antigen processing and presentation
  • intracellular signal transduction

cellular COMPONENT

Where in the cell the gene product is active
  • cytoplasm
  • membrane
  • external side of plasma membrane
  • extracellular region
  • plasma membrane
  • host cell
  • cell surface

molecular FUNCTION

What the gene product does at the molecular level
  • virion binding
  • peptide antigen binding
  • mannose binding
  • protein binding
  • metal ion binding
  • viral receptor activity
  • carbohydrate binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.