CSF2RB Gene Summary

The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
CSF2RB
Official Name
colony stimulating factor 2 receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:2436]
Ensembl ID
ENSG00000100368
Bio databases IDs NCBI: 1439 Ensembl: ENSG00000100368
Aliases colony stimulating factor 2 receptor subunit beta, beta common cytokine receptor, beta-GM-CSF receptor
Synonyms
AI848964,AIC2B,Bc,Beta C,betaGMR,beta IL-3,CD131,CDw131,colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage),colony stimulating factor 2 receptor subunit beta,colony stimulating factor 2 receptor subunit β,colony stimulating factor 2 receptor, β, low-affinity (granulocyte-macrophage),Csf2r,Csf2rb1,Csfgmrb,Gm-csfr beta IT,Gm csf receptor β,Gmcsf receptor β c,GM-CSFR β,Gm-csfr β IT,Gmr β c,Granulocyte-macrophage colony stimulating factor 2 receptor, beta 1,Granulocyte-macrophage colony stimulating factor 2 receptor, β 1,Il3r,IL3RB,Il3rb1,IL3R beta 1,IL3R β 1,IL5RB,Il-5Rbetac,Il-5 receptor β chain,Il-5Rβc,SMDP5,β C,β chain of il 3 receptor,β IL-3
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • endodomain
  • extracellular domain
  • interleukin-5 receptor
  • Box motif
  • signaling receptor activity
  • Purple acid Phosphatase, N-terminal domain
  • Fibronectin type 3 domain
  • Interferon-alpha/beta receptor, fibronectin type III
  • interleukin-3 receptor
  • protein binding
  • Hemopoietin domain
  • TRAF6 binding domain
  • Box I domain
  • Box II domain
  • N-linked glycosylation site
  • cytoplasmic domain
  • FN3
  • extracellular ligand binding domain
  • transmembrane domain
  • intracellular domain
  • membrane-proximal domain
  • transmembrane receptor
  • tyrosine phosphorylation site
  • coreceptor

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • chronic myeloid leukemia
  • atopic dermatitis
  • HIV infection
  • cytomegalovirus retinitis
  • sarcoma
  • rheumatoid arthritis
  • infection
  • ankylosing spondylitis
  • lymphoma
  • graft-vs-host disease
regulated by
  • IFNG
  • lipopolysaccharide
  • interferon alpha
  • STUB1
  • ZBTB32
  • FN1
  • Immunoglobulin
  • dexamethasone
  • Francisella tularensis subsp. holarctica LVS
  • TNF
regulates
role in cell
  • proliferation
  • cell viability
  • phosphorylation in
  • survival
  • apoptosis
  • activation in
  • growth
  • migration
  • expression in
  • differentiation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • Cytoplasm
  • cell surface
  • cellular membrane
  • vesicles
  • perikaryon
  • dendrites

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the CSF2RB gene, providing context for its role in the cell.

biological PROCESS

Functions and activities the gene product is involved in
  • granulocyte-macrophage colony-stimulating factor signaling pathway
  • signal transduction
  • interleukin-5-mediated signaling pathway
  • interleukin-3-mediated signaling pathway
  • cytokine-mediated signaling pathway
  • immunoglobulin mediated immune response
  • positive regulation of leukocyte proliferation
  • response to lipopolysaccharide
  • respiratory gaseous exchange
  • cellular response to interleukin-3
  • JAK-STAT cascade

cellular COMPONENT

Where in the cell the gene product is active
  • granulocyte macrophage colony-stimulating factor receptor complex
  • external side of plasma membrane
  • plasma membrane

molecular FUNCTION

What the gene product does at the molecular level
  • coreceptor activity
  • protein binding
  • interleukin-3 receptor activity
  • signaling receptor activity
  • interleukin-5 receptor activity
  • cytokine receptor activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.