GUCY1A1 Gene Summary
Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Details
| Type | Protein Coding |
| Official Symbol | GUCY1A1 |
| Official Name | guanylate cyclase 1 soluble subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:4685] |
| Ensembl ID | ENSG00000164116 |
| Bio databases IDs | |
| Aliases | guanylate cyclase 1 soluble subunit alpha 1 |
| Synonyms | 1200016O07Rik,Alpha 1 GC,GC-1alpha,GC-1α,GC-SA3,GC-S-alpha-1,GCS-alpha-3,GC-S-α-1,GCS-α-3,guanylate cyclase 1, soluble, alpha 1,Guanylate cyclase 1, soluble, alpha 3,guanylate cyclase 1 soluble subunit alpha 1,guanylate cyclase 1 soluble subunit α 1,guanylate cyclase 1, soluble, α 1,Guanylate cyclase 1, soluble, α 3,GUANYLATE CYCLASE alpha 1,GUANYLATE CYCLASE α 1,GUC1A3,GUCA3,GUCSA3,GUCY1A3,MYMY6,NO-GC1,NO receptor guanylyl cyclase alpha1 subunit,SGC,sGC-alpha1,SGC-α-1,α 1 GC |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Heme NO binding associated
- cytidylate cyclase
- signaling receptor activity
- regulatory domain
- binding protein
- adenylate cyclase
- catalytic domain
- guanylate cyclase
- Class III nucleotidyl cyclases
- enzyme
- protein binding
- Adenylyl- / guanylyl cyclase, catalytic domain
Pathways
Biological processes and signaling networks where the GUCY1A1 gene plays a role, providing insight into its function and relevance in health or disease.
- Antiproliferative Role of Somatostatin Receptor 2
- Apelin Adipocyte Signaling Pathway
- Apelin Endothelial Signaling Pathway
- Cardiac β-adrenergic Signaling
- CDK5 Signaling
- Cellular Effects of Sildenafil (Viagra)
- Corticotropin Releasing Hormone Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Dopamine Receptor Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endocannabinoid Developing Neuron Pathway
- Endothelin-1 Signaling
- eNOS Signaling
- IL-1 Signaling
- Inhibition of Angiogenesis by TSP1
- Leptin Signaling in Obesity
- Melanocyte Development and Pigmentation Signaling
- P2Y Purinergic Receptor Signaling Pathway
- Phototransduction Pathway
- PPARα/RXRα Activation
- Protein Kinase A Signaling
- Renin-Angiotensin Signaling
- Thrombin Signaling
- α-Adrenergic Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- diabetic nephropathy
- heart failure
- disorder of coronary artery
- coronary disease
- metabolic syndrome X
- cardiovascular disorder
- cirrhosis
- congestive heart failure
- myocardial infarction
role in cell
- proliferation
- number
- cell viability
- expression in
- migration
- aggregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- glutaminergic synapse
- outer membranes
- Plasma Membrane
- cytosol
- primary cilia
- caveolae
- dendrite initial segments
- synapse
- perikaryon
- axons
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the GUCY1A1 gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- cGMP biosynthetic process
- response to oxygen levels
- cGMP-mediated signaling
- nitric oxide mediated signal transduction
- relaxation of vascular smooth muscle
- blood circulation
- positive regulation of nitric oxide mediated signal transduction
- regulation of blood pressure
- nitric oxide-cGMP-mediated signaling pathway
cellular COMPONENT
Where in the cell the gene product is active
- guanylate cyclase complex, soluble
- cytosol
molecular FUNCTION
What the gene product does at the molecular level
- GTP binding
- protein binding
- signaling receptor activity
- guanylate cyclase activity
- heme binding