IL10RB Gene Summary
The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | IL10RB |
| Official Name | interleukin 10 receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:5965] |
| Ensembl ID | ENSG00000243646 |
| Bio databases IDs | |
| Aliases | interleukin 10 receptor subunit beta |
| Synonyms | 6620401D04RIK,CDW210B,CRF2-4,CRFB4,D16H21S58,D21S58,D21S58h,D21S66,IBD25,IL-10R2,Il10r beta,Il 10r β,interleukin 10 receptor, beta,interleukin 10 receptor subunit beta,interleukin 10 receptor subunit β,interleukin 10 receptor, β,Interleukin 10 receptor β chain,RGD1560373 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- cytoplasmic domain
- FN3
- interleukin-10 receptor
- protein binding
- Fibronectin type 3 domain
- Interferon-alpha/beta receptor, fibronectin type III
- Tissue factor
- transmembrane receptor
- coreceptor
Pathways
Biological processes and signaling networks where the IL10RB gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- autosomal recessive inflammatory bowel disease type 25
- susceptibility to hepatitis B virus
- critical COVID-19
- colitis
- chronic colitis
- hyperplasia
- severe COVID-19
- enterocolitis
role in cell
- activation in
- differentiation
- number
- signaling
- inflammatory response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the IL10RB gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- inflammatory response
- immune response
- signal transduction
- cytokine-mediated signaling pathway
- defense response to virus
- positive regulation of JAK-STAT cascade
cellular COMPONENT
Where in the cell the gene product is active
- membrane
- interleukin-28 receptor complex
- plasma membrane
molecular FUNCTION
What the gene product does at the molecular level
- interleukin-10 receptor activity
- coreceptor activity
- protein binding
- signaling receptor activity