Btg3 Gene Summary [Rat]
Involved in response to oxidative stress. Predicted to be active in cytoplasm and nucleus. Orthologous to human BTG3 (BTG anti-proliferation factor 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Btg3 |
| Official Name | BTG anti-proliferation factor 3 [Source:RGD Symbol;Acc:2226] |
| Ensembl ID | ENSRNOG00000001555 |
| Bio databases IDs | |
| Aliases | BTG anti-proliferation factor 3 |
| Synonyms | ANA, ANA/BTG3, APRO4, BTG anti-proliferation factor 3, TOB5, TOB55, TOFA |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Btg3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- BTG family
- protein binding
- proline rich domain
- tob/btg1 family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- cancer
- liver cancer
- hepatocellular carcinoma
- lung cancer
- diabetic ketoacidosis
- prostate cancer
- organismal death
- Marfan syndrome
- thoracic cancer
role in cell
- binding in
- phosphorylation in
- proliferation
- expression in
- cell death
- cell cycle progression
- activation in
- differentiation
- binding
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Btg3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
- negative regulation of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding