Aff1 Gene Summary [Rat]
Predicted to be involved in regulation of gene expression. Predicted to act upstream of or within positive regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be part of super elongation complex. Orthologous to human AFF1 (ALF transcription elongation factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aff1 |
| Official Name | AF4/FMR2 family, member 1 [Source:RGD Symbol;Acc:1307940] |
| Ensembl ID | ENSRNOG00000002232 |
| Bio databases IDs | |
| Aliases | AF4/FMR2 family, member 1 |
| Synonyms | 9630032B01Rik, AF4, AF4/FMR2 family, member 1, AF4-MLL, ALF transcription elongation factor 1, FEL, MLL/AF4, MLLT2, Mllt2h, PBM1, Rob |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aff1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- serine-rich region
- AF4 interaction motif
- nuclear localization sequence
- ALF homology domain
- AFF4 C-terminal homology domain
- AF-4 proto-oncoprotein C-terminal region
- protein binding
- MLL C-terminal homology domain
- transcription factor activity
- MLL N-terminal homology domain
- AF-4 proto-oncoprotein N-terminal region
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- abdominal cancer
- cancer
- papillomatosis
- squamous cell cancer
- uterine cancer
- tumorigenesis
- female genital tract cancer
- pelvic cancer
- urogenital cancer
- systemic lupus erythematosus
role in cell
- expression in
- growth
- activation in
- quantity
- recruitment in
- number
- differentiation
- abnormal morphology
- interaction in
- elongation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aff1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of gene expression
Cellular Component
Where in the cell the gene product is active
- transcription elongation factor complex
- ELL-EAF complex
Molecular Function
What the gene product does at the molecular level
- protein binding