Cap1 Gene Summary [Rat]
Predicted to enable actin binding activity and adenylate cyclase binding activity. Predicted to be involved in several processes, including actin filament organization; cAMP-mediated signaling; and modification of postsynaptic actin cytoskeleton. Predicted to act upstream of or within actin cytoskeleton organization; ameboidal-type cell migration; and receptor-mediated endocytosis. Predicted to be located in cortical actin cytoskeleton. Predicted to be active in several cellular components, including glutamatergic synapse; postsynapse; and presynapse. Orthologous to human CAP1 (cyclase associated actin cytoskeleton regulatory protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cap1 |
| Official Name | cyclase associated actin cytoskeleton regulatory protein 1 [Source:RGD Symbol;Acc:620309] |
| Ensembl ID | ENSRNOG00000013492 |
| Bio databases IDs | |
| Aliases | cyclase associated actin cytoskeleton regulatory protein 1 |
| Synonyms | Adenylyl cyclase-associated, CAP, CAP1-PEN, Cap adenylate cyclase associated protein 1, cyclase associated actin cytoskeleton regulatory protein 1, Mch1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Adenylate cyclase associated (CAP) N terminal
- Adenylate cyclase associated (CAP) C terminal
- central domain
- Tubulin binding cofactor C
- protein binding
Pathways
Biological processes and signaling networks where the Cap1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal dominant Emery-Dreifuss muscular dystrophy
- essential thrombocythemia
- juvenile dermatomyositis
- colorectal cancer
- early onset hypertension
- neonatal late-onset sepsis
- Duchenne muscular dystrophy
- postmenopausal osteoporosis
role in cell
- growth
- activation in
- growth in
- migration
- phosphorylation in
- development
- morphogenesis
- depolymerization
- organization
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- myelin enriched fraction
- glutaminergic synapse
- cortical actin cytoskeleton
- azurophil granule lumen
- Cytoplasm
- presynaptic regions
- Extracellular Space
- postsynaptic region
- actin cytoskeleton
- cytosol
- membrane ruffles
- growth cone
- actin stress fibers
- phagosomes
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ameboidal cell migration
- signal transduction
- cell morphogenesis
- establishment or maintenance of cell polarity
- actin filament organization
- activation of adenylate cyclase activity
- receptor-mediated endocytosis
- cAMP-mediated signaling
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
- extracellular region
- azurophil granule lumen
- cortical actin cytoskeleton
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- adenylate cyclase binding