Slc22a1 Gene Summary [Rat]
Enables several functions, including dopamine:sodium symporter activity; identical protein binding activity; and organic cation transmembrane transporter activity. Involved in several processes, including metanephric proximal tubule development; monoamine transport; and monoatomic ion transmembrane transport. Located in apical plasma membrane and basolateral plasma membrane. Used to study acute kidney failure. Biomarker of asthma; extrahepatic cholestasis; and intrahepatic cholestasis. Orthologous to human SLC22A1 (solute carrier family 22 member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc22a1 |
| Official Name | solute carrier family 22 member 1 [Source:RGD Symbol;Acc:3224] |
| Ensembl ID | ENSRNOG00000016337 |
| Bio databases IDs | |
| Aliases | solute carrier family 22 member 1 |
| Synonyms | HOCT1, OCT1, oct1 cds, Orct1, Roct1, solute carrier family 22 member 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc22a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- benzoate transport
- pyrimidine nucleoside transporter
- MFS transporter, sugar porter (SP) family
- Multidrug resistance protein
- Major Facilitator Superfamily
- phosphate:H+ symporter
- identical protein binding
- monoamine transporter
- spermidine transporter
- thiamin transporter
- toxin transporter
- drug resistance transporter, Bcr/CflA subfamily
- carnitine transporter
- putrescine transporter
- dopamine:sodium symporter
- neurotransmitter transporter
- protein binding
- organic anion transporter
- prostaglandin transporter
- noradrenaline:sodium symporter
- organic cation transporter
- Sugar (and other) transporter
- xenobiotic transporter
- acetylcholine transporter
- cation transport protein
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- essential hypertension
- epithelial cancer
- non-insulin-dependent diabetes mellitus
- acute myeloid leukemia
- hepatocellular carcinoma
- liver cancer
- endometriosis
- Parkinson disease
- spondylarthritis
- progressive familial intrahepatic cholestasis type 1
regulates
- dopamine
- norepinephrine
- 5-hydroxytryptamine
- triacylglycerol
- quaternary ammonium compound
- 3-iodobenzylguanidine
- thiamine
- purine base
- Hb A
- diaminneplatinum(II)-chlorocholylglycinate
role in cell
- uptake in
- growth
- production in
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- nuclear fraction
- cellular membrane
- apical membrane
- basolateral membrane
- basal membrane
- lateral plasma membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc22a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- norepinephrine transport
- quaternary ammonium group transport
- dopamine transport
- organic cation transport
- acetylcholine transport
- norepinephrine uptake
- neurotransmitter transport
- serotonin uptake
- epinephrine transport
- purine-containing compound transmembrane transport
- serotonin transport
- xenobiotic metabolic process
- establishment or maintenance of transmembrane electrochemical gradient
- xenobiotic transport
- spermidine transport
- putrescine transport
- metanephric proximal tubule development
- thiamine transmembrane transport
- monoamine transport
- thiamine transport
- prostaglandin transport
Cellular Component
Where in the cell the gene product is active
- basal plasma membrane
- lateral plasma membrane
- membrane
- basolateral plasma membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- pyrimidine nucleoside transmembrane transporter activity
- xenobiotic transporter activity
- putrescine transmembrane transporter activity
- identical protein binding
- thiamine transmembrane transporter activity
- organic cation transmembrane transporter activity
- quaternary ammonium group transmembrane transporter activity
- prostaglandin transmembrane transporter activity
- dopamine:sodium symporter activity
- acetylcholine transmembrane transporter activity
- monoamine transmembrane transporter activity
- norepinephrine:sodium symporter activity
- organic anion transmembrane transporter activity
- secondary active organic cation transmembrane transporter activity
- neurotransmitter transporter activity
- protein binding
- spermidine transmembrane transporter activity
- toxin transporter activity