Ctsl Gene Summary [Rat]
Enables kininogen binding activity; peptidase activity; and peptide binding activity. Involved in several processes, including autophagic cell death; decidualization; and response to odorant. Located in several cellular components, including external side of plasma membrane; microvillus; and perikaryon. Used to study hepatocellular carcinoma. Biomarker of several diseases, including brain ischemia; hyperthyroidism; muscular atrophy; otitis media; and pancreatitis. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to several human genes including CTSV (cathepsin V). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ctsl |
| Official Name | cathepsin L [Source:RGD Symbol;Acc:2448] |
| Ensembl ID | ENSRNOG00000018566 |
| Bio databases IDs | |
| Aliases | cathepsin L |
| Synonyms | cathepsin L, CATHL, CatL, Ctsl1, Ctsl2 |
| Species | Rat, Rattus norvegicus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ctsl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptide binding
- histone binding
- Cathepsin propeptide inhibitor domain (I29)
- Peptidase_C1
- enzyme
- protein binding
- fibronectin binding
- endopeptidase
- cysteine-type peptidase
- cysteine endopeptidase
- binding protein
- aminopeptidase
- collagen binding
- cysteine-type carboxypeptidase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Extracellular Space
- apical compartment
- Nucleus
- Plasma Membrane
- lysosome
- Golgi Apparatus
- plasma membrane extracellular face
- nucleoli
- perinuclear vesicles
- cytoplasmic vesicles
- multivesicular bodies
- secretory granules
- microvilli
- perikaryon
- chromaffin vesicles