P2ry2 Gene Summary [Rat]
Enables A1 adenosine receptor binding activity; ATP binding activity; and G protein-coupled UTP receptor activity. Involved in several processes, including positive regulation of penile erection; regulation of presynaptic cytosolic calcium ion concentration; and regulation of secretion by cell. Located in apical plasma membrane; basolateral plasma membrane; and early endosome. Is active in glutamatergic synapse and presynaptic active zone membrane. Used to study impotence. Orthologous to human P2RY2 (purinergic receptor P2Y2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | P2ry2 |
| Official Name | purinergic receptor P2Y2 [Source:RGD Symbol;Acc:62088] |
| Ensembl ID | ENSRNOG00000019283 |
| Bio databases IDs | |
| Aliases | purinergic receptor P2Y2 |
| Synonyms | HP2U, P2RU1, P2U, P2U1, P2UR, P2Y2, P2Y2R, purinergic receptor P2Y2, purinergic receptor P2Y, G-protein coupled 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat P2ry2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- signaling receptor activity
- UTP-activated nucleotide receptor
- purinergic G-protein coupled nucleotide receptor
- G-protein-coupled receptor binding
- ATP binding
- RGD motif
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- extracellular loop
- 7 transmembrane receptor (rhodopsin family)
- tail domain
- PXXP motif
Pathways
Biological processes and signaling networks where the P2ry2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- liver neoplasia
- cancer
- weight gain
- dental caries
- pneumonitis
- lung cancer
- thermal hypalgesia
role in cell
- accumulation in
- production in
- expression in
- proliferation
- phosphorylation in
- growth
- migration
- synthesis in
- cellular infiltration by
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- cell surface
- cellular membrane
- apical membrane
- presynaptic membrane
- basolateral membrane
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat P2ry2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- phospholipase C-activating G-protein coupled receptor signaling pathway
- positive regulation of mucus secretion
- cellular response to ATP
- cellular ion homeostasis
- G-protein coupled purinergic nucleotide receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- UTP-activated nucleotide receptor activity
- protein binding
- signaling receptor activity
- G-protein coupled purinergic nucleotide receptor activity
- A1 adenosine receptor binding