Pfkfb4 Gene Summary [Rat]
Enables 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in fructose 2,6-bisphosphate metabolic process. Predicted to be active in cytosol. Orthologous to human PFKFB4 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pfkfb4 |
| Official Name | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 [Source:RGD Symbol;Acc:3310] |
| Ensembl ID | ENSRNOG00000020656 |
| Bio databases IDs | |
| Aliases | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 |
| Synonyms | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4, C230090D14, LOC100911725, PFKB4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pfkfb4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- NK
- Histidine phosphatase superfamily (branch 1)
- Phosphoglycerate mutase family
- fructose-2,6-bisphosphate 2-phosphatase
- protein binding
- alpha-ribazole phosphatase
- Histidine phosphatase domain
- 6-phosphofructo-2-kinase
- AAA domain
Pathways
Biological processes and signaling networks where the Pfkfb4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- breast carcinoma
- renal clear cell adenocarcinoma
- renal clear cell cancer
- endometriosis
- breast cancer
- organismal death
- myocardial infarction
- Alzheimer disease
role in cell
- expression in
- production in
- growth
- proliferation
- phosphorylation in
- migration
- maturation
- binding in
- invasiveness
- healing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- cellular membrane
- cytosol
- Z line
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pfkfb4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fructose 2,6-bisphosphate metabolic process
- fructose metabolic process
- carbohydrate phosphorylation
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- fructose-2,6-bisphosphate 2-phosphatase activity
- 6-phosphofructo-2-kinase activity