Ms4a2 Gene Summary [Rat]
Enables SH2 domain binding activity; phosphoprotein binding activity; and protein kinase binding activity. Involved in positive regulation of mast cell degranulation and regulation of release of sequestered calcium ion into cytosol. Located in endosome. Human ortholog(s) of this gene implicated in asthma; atopic dermatitis; and rhinitis. Orthologous to human MS4A2 (membrane spanning 4-domains A2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ms4a2 |
| Official Name | membrane spanning 4-domains A2 [Source:RGD Symbol;Acc:2598] |
| Ensembl ID | ENSRNOG00000020993 |
| Bio databases IDs | |
| Aliases | membrane spanning 4-domains A2 |
| Synonyms | APY, ATOPY, Fce1b, Fc epsilon ri beta, FCER1B, FCERI, FCIGA, FcMR I β Chain, FcRB, Fcrbeta, FcR β, Fc ε ri β, High affinity immunoglobulin ε receptor β subunit, Ige fc receptor β subunit, IGEL, IGER, IGHER, membrane spanning 4-domains A2, membrane-spanning 4-domains, subfamily A, member 2, MS4A1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ms4a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- cytoplasmic domain
- SH2-domain binding
- phosphoprotein binding
- protein binding
- membrane-proximal domain
- IgE receptor
- CD20-like family
- transmembrane receptor
- IgE binding
Pathways
Biological processes and signaling networks where the Ms4a2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cystic fibrosis
- childrens interstitial lung disease
- allergic asthma
- chronic rhinosinusitis with nasal polyps
- angioedema
- asthma
- food allergy
- chronic idiopathic urticaria
- IgE-mediated food allergy
- chronic urticaria
role in cell
- apoptosis
- transactivation in
- phosphorylation in
- degranulation
- reorganization
- function
- reorganization in
- translocation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- endosomes
- cytoplasmic face of plasma membrane
- plasma membrane extracellular face
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ms4a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- cell surface receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- Fc-epsilon receptor I complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- IgE binding