Pde3a Gene Summary [Rat]
Predicted to enable 3',5'-cyclic-nucleotide phosphodiesterase activity; estrogen binding activity; and nuclear estrogen receptor activity. Involved in negative regulation of apoptotic process; negative regulation of cAMP/PKA signal transduction; and oocyte maturation. Predicted to be located in membrane. Predicted to be active in cytosol. Biomarker of obesity and pulmonary hypertension. Human ortholog(s) of this gene implicated in hypertension and brachydactyly syndrome. Orthologous to human PDE3A (phosphodiesterase 3A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pde3a |
| Official Name | phosphodiesterase 3A [Source:RGD Symbol;Acc:61942] |
| Ensembl ID | ENSRNOG00000025042 |
| Bio databases IDs | |
| Aliases | phosphodiesterase 3A |
| Synonyms | A930022O17Rik, CGI-PDE, CGI-PDE-A, HTNB, NONFUNCTIONAL FOLATE binding, Phosphodiesterase 3a, phosphodiesterase 3A, cGMP inhibited, RNPDE3A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pde3a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3'5'-cyclic nucleotide phosphodiesterase
- 14-3-3 binding domain
- hormone binding
- cGMP-inhibited cyclic-nucleotide phosphodiesterase
- 3',5'-cyclic-GMP phosphodiesterase
- catalytic domain
- cAMP-specific phosphodiesterase
- enzyme
- protein binding
- 3',5'-cyclic-nucleotide phosphodiesterase
- Metal dependent phosphohydrolases with conserved 'HD' motif
- cyclic-nucleotide phosphodiesterase
- estrogen receptor
- HDc
Pathways
Biological processes and signaling networks where the Pde3a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pulmonary emphysema
- nephrosis
- diabetic nephropathy
- non-insulin-dependent diabetes mellitus
- contrast induced nephropathy
- congestive heart failure
- ischemic stroke
- stroke
- hypertension
- renal failure
role in cell
- expression in
- phosphorylation in
- proliferation
- binding in
- apoptosis
- growth
- development
- morphology
- maturation
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- cytosol
- Z line
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pde3a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cGMP-mediated signaling
- positive regulation of oocyte development
- G-protein coupled receptor signaling pathway
- regulation of meiosis
- apoptotic signaling pathway
- response to xenobiotic stimulus
- negative regulation of vascular permeability
- negative regulation of cAMP-mediated signaling
- steroid hormone mediated signaling pathway
- positive regulation of vascular permeability
- regulation of ribonuclease activity
- cellular response to transforming growth factor beta stimulus
- oocyte maturation
- cellular response to cGMP
- negative regulation of apoptotic process
- lipid metabolic process
- cAMP-mediated signaling
Cellular Component
Where in the cell the gene product is active
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
- protein binding
- metal ion binding
- estrogen receptor activity
- 3',5'-cyclic-GMP phosphodiesterase activity
- 3',5'-cyclic-AMP phosphodiesterase activity
- 3',5'-cyclic-nucleotide phosphodiesterase activity