RAB11FIP1 Gene Summary [Human]
This gene encodes one of the Rab11-family interacting proteins (Rab11-FIPs), which play a role in the Rab-11 mediated recycling of vesicles. The encoded protein may be involved in endocytic sorting, trafficking of proteins including integrin subunits and epidermal growth factor receptor (EGFR), and transport between the recycling endosome and the trans-Golgi network. Alternative splicing results in multiple transcript variants. A pseudogene is described on the X chromosome. [provided by RefSeq, Dec 2013]
Details
| Type | Protein Coding |
| Official Symbol | RAB11FIP1 |
| Official Name | RAB11 family interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:30265] |
| Ensembl ID | ENSG00000156675 |
| Bio databases IDs | |
| Aliases | RAB11 family interacting protein 1 |
| Synonyms | 2010200K21Rik, 4833414G05Rik, NOEL1A, RAB11 family interacting protein 1, RAB11 family interacting protein 1 (class I), RCP, RGD1562965 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RAB11FIP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rab11 binding domain
- FIP domain
- Rab4 binding domain
- protein binding
- Protein kinase C conserved region 2 (CalB)
- C2 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- ductal breast carcinoma
- ductal breast cancer
- breast cancer
- chickenpox
role in cell
- expression in
- proliferation
- phosphorylation in
- invasion by
- recycling
- invasion
- tubulation
- haptotaxis
- scattering
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- tubular endosomal network
- intracellular membrane-bounded organelle
- perinuclear region
- cellular membrane
- cytosol
- perinuclear space
- perinuclear vesicles
- presynaptic terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RAB11FIP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of adiponectin secretion
- protein transport
- regulated secretory pathway
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- cytosol
- phagocytic vesicle membrane
- recycling endosome
Molecular Function
What the gene product does at the molecular level
- small GTPase binding