Bid Gene Summary [Rat]
Predicted to enable ubiquitin protein ligase binding activity. Involved in several processes, including apoptotic mitochondrial changes; positive regulation of autophagy in response to ER overload; and positive regulation of release of cytochrome c from mitochondria. Located in cytosol and mitochondrion. Used to study pre-malignant neoplasm. Biomarker of bronchopulmonary dysplasia; epilepsy; status epilepticus; and traumatic brain injury. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human BID (BH3 interacting domain death agonist). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bid |
| Official Name | BH3 interacting domain death agonist [Source:RGD Symbol;Acc:620160] |
| Ensembl ID | ENSRNOG00000012439 |
| Bio databases IDs | |
| Aliases | BH3 interacting domain death agonist |
| Synonyms | 2700049M22Rik, BH3 interacting domain death agonist, cBid, FP497 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bid often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- caspase regulator
- death receptor binding
- ubiquitin protein ligase binding
- BH3 interacting domain (BID)
- BH3-like domain
- granzyme B cleavage site
- Bcl-2 homology 3 domain
- alpha helix
- protein binding
- caspase-8 cleavage site
- cardiolipin binding domain
Pathways
Biological processes and signaling networks where the Bid gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Apoptosis Signaling
- ATM Signaling
- CD27 Signaling in Lymphocytes
- Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells
- Death Receptor Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Granzyme B Signaling
- Induction of Apoptosis by HIV1
- Mitochondrial Dysfunction
- Molecular Mechanisms of Cancer
- Myc Mediated Apoptosis Signaling
- Retinoic acid Mediated Apoptosis Signaling
- Role of PKR in Interferon Induction and Antiviral Response
- Small Cell Lung Cancer Signaling
- TNFR1 Signaling
- Tumoricidal Function of Hepatic Natural Killer Cells
- TWEAK Signaling
- Type I Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- epithelial neoplasia
- benign neoplasia
- epithelial cancer
- adenoma formation
- COVID-19
- fulminant hepatitis
- colorectal adenoma
- colorectal adenoma formation
- fibrosis
role in cell
- production in
- molecular cleavage in
- apoptosis
- phosphorylation in
- transmembrane potential
- cell death
- permeabilization
- binding
- quantity
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum fraction
- membrane fraction
- mitochondrial fraction
- outer membranes
- cellular membrane
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- Mitochondria
- cytosol
- mitochondrial membrane
- mitochondrial outer membrane
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bid gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of T cell proliferation
- macromolecular complex assembly
- positive regulation of fibroblast apoptotic process
- positive regulation of release of cytochrome c from mitochondria
- signal transduction in response to DNA damage
- induction of apoptosis via death domain receptors
- establishment of protein localization in membrane
- mitochondrial ATP synthesis coupled electron transport
- hepatocyte apoptotic process
- protein targeting to mitochondrion
- positive regulation of mitochondrial membrane potential
- apoptotic mitochondrial changes
- positive regulation of apoptotic process
- release of cytochrome c from mitochondria
- regulation of G1/S transition of mitotic cell cycle
- positive regulation of extrinsic apoptotic signaling pathway
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- regulation of epithelial cell proliferation
- positive regulation of intrinsic apoptotic signaling pathway
- positive regulation of protein complex assembly
- neuron apoptotic process
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- membrane
- cytosol
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin protein ligase binding
- death receptor binding