OPRK1 Gene Summary

This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]

Details

Type
Protein Coding
Official Symbol
OPRK1
Official Name
opioid receptor kappa 1 [Source:HGNC Symbol;Acc:HGNC:8154]
Ensembl ID
ENSG00000082556
Bio databases IDs NCBI: 4986 Ensembl: ENSG00000082556
Aliases opioid receptor kappa 1
Synonyms
FLJ13136,K1or,KAPPA OPIOID receptor,KOP,KOR,K-OR-1,MSL-1,OPIATE receptor KAPPA,OPIATE receptor κ,opioid receptor kappa 1,opioid receptor, kappa 1,opioid receptor κ 1,opioid receptor, κ 1,OPRK,Oprk2,R21,κ Opiate Receptor,κ OPIOID receptor
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • G-protein coupled receptor
  • 14-3-3 binding domain
  • G-protein coupled peptide receptor
  • opioid receptor
  • intracellular loop
  • Cholecystokinin A receptor, N-terminal
  • transmembrane domain
  • 7 transmembrane receptor (rhodopsin family)
  • tail domain
  • protein binding
  • receptor binding
  • seven-transmembrane G protein-coupled receptor superfamily

Pathways

Biological processes and signaling networks where the OPRK1 gene plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • breast cancer
  • postoperative pain
  • liver failure
  • alcoholism
  • spine abnormality
  • cancer
  • opioid overdose
  • opioid dependence
  • heroin dependence
  • opioid-related disorder
regulated by
  • AGN193109
  • picrotoxin
  • tretinoin
  • U 50488H
  • dynorphin (1-13)
  • ICI 204448
  • brefeldin A
  • morphine
  • sucrose
  • beta-estradiol
regulates
role in cell
  • expression in
  • phosphorylation in
  • differentiation
  • response by
  • formation by
  • recruitment in
  • coupling in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • membrane fraction
  • synaptic vesicle membrane
  • cell surface
  • cellular membrane
  • filamentous network
  • sarcoplasmic reticulum
  • Mitochondria
  • cytosol
  • presynaptic membrane
  • postsynaptic membrane
  • nucleoplasm
  • sarcolemma
  • transverse tubules
  • perikaryon
  • dendrites
  • axon terminals

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the OPRK1 gene, providing context for its role in the cell.

biological PROCESS

Functions and activities the gene product is involved in
  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
  • response to estrogen stimulus
  • regulation of saliva secretion
  • eating behavior
  • maternal behavior
  • response to ethanol
  • adenylate cyclase-inhibiting opioid receptor signaling pathway
  • locomotory behavior
  • immune response
  • response to insulin stimulus
  • behavioral response to cocaine
  • cellular response to glucose stimulus
  • defense response to virus
  • sensory perception of temperature stimulus
  • opioid receptor signaling pathway
  • synaptic transmission
  • response to nicotine
  • phospholipase C-activating G-protein coupled receptor signaling pathway
  • sensory perception
  • positive regulation of p38MAPK cascade
  • neuropeptide signaling pathway
  • cellular response to lipopolysaccharide
  • sensory perception of pain
  • negative regulation of luteinizing hormone secretion
  • positive regulation of dopamine secretion

cellular COMPONENT

Where in the cell the gene product is active
  • presynaptic membrane
  • sarcoplasmic reticulum
  • perikaryon
  • neuron projection
  • plasma membrane
  • axon terminus
  • nucleoplasm
  • dendrite
  • T-tubule
  • postsynaptic membrane
  • membrane
  • mitochondrion
  • cytosol
  • synaptic vesicle membrane

molecular FUNCTION

What the gene product does at the molecular level
  • dynorphin receptor activity
  • opioid receptor activity
  • neuropeptide binding
  • protein binding
  • receptor serine/threonine kinase binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.