STK11 Gene Summary
The protein encoded by this gene is a serine/threonine kinase that regulates cell polarity and energy metabolism and functions as a tumor suppressor. Mutations in this gene have been associated with the autosomal dominant Peutz-Jeghers syndrome, as well as with skin, pancreatic, and testicular cancers. [provided by RefSeq, May 2022]
Details
| Type | Protein Coding |
| Official Symbol | STK11 |
| Official Name | serine/threonine kinase 11 [Source:HGNC Symbol;Acc:HGNC:11389] |
| Ensembl ID | ENSG00000118046 |
| Bio databases IDs | |
| Aliases | serine/threonine kinase 11, polarization-related protein LKB1 |
| Synonyms | hLKB1,LKB1,LKB1-L,LKB1(S),Par-4,PJS,serine/threonine kinase 11,Stk11 isoform 2,Stk11 short isoform |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- N-terminal regulatory domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- C-terminal regulatory domain
- Protein tyrosine and serine/threonine kinase
- LRR-domain binding
- ATP binding
- p53 binding
- protein binding
- magnesium ion binding
- Protein kinase domain
- phosphorylation site
- kinase
- protein kinase activator
- Serine/Threonine protein kinases, catalytic domain
- nucleotide-binding domain
- kinase domain
- binding protein
- Protein Kinases, catalytic domain
- Kinase-like
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the STK11 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- acute myeloid leukemia
- myelodysplastic syndrome
- acute lymphoblastic leukemia
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- cancer
- epithelial cancer
role in cell
- activation in
- phosphorylation in
- G1 phase
- S phase
- expression in
- apoptosis
- survival
- quantity
- proliferation
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cilia
- cellular membrane
- Nucleus
- basal bodies
- centrosome
- Mitochondria
- cytosol
- nucleoplasm
- Z line
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the STK11 gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
- epithelial cell proliferation involved in prostate gland development
- protein autophosphorylation
- protein phosphorylation
- positive regulation of gluconeogenesis
- regulation of dendrite morphogenesis
- cellular response to UV-B
- response to thyroid hormone stimulus
- positive regulation of axonogenesis
- negative regulation of cell growth
- axonogenesis
- vasculature development
- autophagy
- activation of protein kinase activity
- response to lipid
- regulation of cell cycle
- protein localization to nucleus
- T cell receptor signaling pathway
- Golgi localization
- response to ionizing radiation
- negative regulation of epithelial cell proliferation involved in prostate gland development
- positive regulation of protein localization to nucleus
- signal transduction
- spermatogenesis
- protein dephosphorylation
- anoikis
- positive thymic T cell selection
- response to DNA damage stimulus
- negative regulation of canonical Wnt receptor signaling pathway
- tissue homeostasis
- regulation of protein kinase B signaling cascade
- positive regulation of autophagy
- regulation of cell growth
- signal transduction by p53 class mediator resulting in induction of apoptosis
- glucose homeostasis
- establishment of cell polarity
- G1 to G0 transition
- response to glucagon stimulus
- response to activity
- regulation of Wnt receptor signaling pathway
- peptidyl-threonine phosphorylation
- positive regulation of transforming growth factor beta receptor signaling pathway
cellular COMPONENT
Where in the cell the gene product is active
- Z disc
- nucleus
- extracellular vesicular exosome
- cytoplasm
- mitochondrion
- membrane
- cytosol
- nucleoplasm
molecular FUNCTION
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- p53 binding
- protein binding
- protein kinase activator activity
- LRR domain binding
- protein serine/threonine kinase activity