IQGAP1 Gene Summary
This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | IQGAP1 |
| Official Name | IQ motif containing GTPase activating protein 1 [Source:HGNC Symbol;Acc:HGNC:6110] |
| Ensembl ID | ENSG00000140575 |
| Bio databases IDs | |
| Aliases | IQ motif containing GTPase activating protein 1, RasGAP-like with IQ motifs |
| Synonyms | D7Ertd237e,D7Ertd257e,HUMORFA01,IQGAP,IQ MOTIF containing GTPASE ACTIVATING,IQ motif containing GTPase activating protein 1,mKIAA0051,p195,SAR1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RasGAP C-terminus
- coiled-coil domain
- GTPase activator
- Ras GTPase Activating Domain
- GTPase-activator protein for Ras-like GTPases
- Calmodulin-binding motif
- Domain with 2 conserved Trp (W) residues
- GTPase inhibitor
- phosphatidylinositol-3,4,5-triphosphate binding
- IQ domain
- WW
- GTPase-activator protein for Ras-like GTPase
- tail domain
- protein kinase binding
- Calponin homology domain
- self-association domain
- calmodulin binding
- protein phosphatase binding
- enzyme binding
- calcium ion binding
- protein domain specific binding
- protein binding
- WW domain
- phosphorylation site
- MAP-kinase scaffold protein
- IQ calmodulin-binding motif
- protein kinase activator
- binding protein
- Cdc42 binding domain
- calponin homology (CH) domain superfamily
- cysteine-histidine rich domain
- Dia1-binding region
Pathways
Biological processes and signaling networks where the IQGAP1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- fibrosis
- liver cancer
- epithelial cancer
- epithelial neoplasia
- Waldenström macroglobulinemia
- Alzheimer disease
- multiple sclerosis
- 4NQO-induced head and neck carcinogenesis
role in cell
- expression in
- activation in
- phosphorylation in
- proliferation
- binding in
- accumulation in
- transcription in
- growth
- invasion by
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- microtubule cytoskeleton
- cortical cytoskeleton
- ruffle
- cortical actin cytoskeleton
- cytoplasmic ribonucleoprotein granule
- cytoskeleton
- cell surface
- cell periphery
- postsynaptic region
- cellular membrane
- focal adhesions
- actin cytoskeleton
- cell cortex
- Nucleus
- Plasma Membrane
- microtubules
- actin filaments
- midbody
- microtubule tips
- intercellular junctions
- cell-cell contacts
- secretory granule membrane
- cytosol
- basal cell surfaces
- cytoplasmic face of plasma membrane
- membrane ruffles
- apical membrane
- basolateral membrane
- lateral plasma membrane
- growth cone
- neurites
- pedicels
- membrane processes
- filopodia
- cell membrane leading edge
- perikaryon
- axons
- exosomes
- lamellipodia
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the IQGAP1 gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- signal transduction
- cellular response to platelet-derived growth factor stimulus
- epidermal growth factor receptor signaling pathway
- fibroblast growth factor receptor signaling pathway
- platelet-derived growth factor receptor signaling pathway
- positive regulation of MAPK cascade
- regulation of mitotic cell cycle
- MAPK cascade
- glomerular visceral epithelial cell development
- cellular response to calcium ion
- positive regulation of protein kinase activity
- cellular response to epidermal growth factor stimulus
- negative regulation of dephosphorylation
- regulation of cytokine production
- fibroblast migration
- cell migration
cellular COMPONENT
Where in the cell the gene product is active
- slit diaphragm
- lateral plasma membrane
- microtubule cytoskeleton
- actin filament
- neuron projection
- plasma membrane
- microtubule
- internal side of plasma membrane
- growth cone
- secretory granule membrane
- nucleus
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
- cell cortex
- ruffle
- actin cytoskeleton
- cytosol
- midbody
- basolateral plasma membrane
- axon
- cortical actin cytoskeleton
- apical plasma membrane
molecular FUNCTION
What the gene product does at the molecular level
- protein kinase binding
- protein domain specific binding
- protein phosphatase binding
- protein serine/threonine kinase activator activity
- GTPase inhibitor activity
- GTPase activator activity
- MAP-kinase scaffold activity
- S100 protein binding
- actin filament binding
- phosphatidylinositol-3,4,5-trisphosphate binding
- calmodulin binding
- protein binding
- calcium ion binding
- cadherin binding
- small GTPase binding
- binding, bridging