GDPD1 Gene Summary
This gene encodes a member of the glycerophosphodiester phosphodiesterase family of enzymes that catalyze the hydrolysis of deacylated glycerophospholipids to glycerol phosphate and alcohol. The encoded protein is localized to the cytoplasm and concentrates near the perinuclear region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | GDPD1 |
| Official Name | glycerophosphodiester phosphodiesterase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:20883] |
| Ensembl ID | ENSG00000153982 |
| Bio databases IDs | |
| Aliases | glycerophosphodiester phosphodiesterase domain containing 1 |
| Synonyms | 2610020H15RIK,FLJ37451,GDE4,glycerophosphodiester phosphodiesterase domain containing 1,RGD1311813 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lysophospholipase
- Glycerophosphoryl diester phosphodiesterase family
- enzyme
- phosphoinositide-specific phospholipase C-like phosphodiesterase catalytic domain
- phosphoric diester hydrolase
Pathways
Biological processes and signaling networks where the GDPD1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- ocular hypertension
- hepatocellular carcinoma
regulates
- N-acylethanolamine
- 1-alkyl-2-lyso-sn-glycero-3-phosphocholine
- 1-alkyl-lysophosphatidic acid
- lysophosphatidic acid
- lysophosphatidylcholine
- phospholipid
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the GDPD1 gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- glycerophospholipid catabolic process
- N-acylethanolamine metabolic process
cellular COMPONENT
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- perinuclear region of cytoplasm
- membrane
- endoplasmic reticulum
molecular FUNCTION
What the gene product does at the molecular level
- lysophospholipase activity
- metal ion binding
- phosphoric diester hydrolase activity