STAT2 Gene Summary
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. The protein mediates innate antiviral activity. Mutations in this gene result in Immunodeficiency 44. [provided by RefSeq, Aug 2020]
Details
| Type | Processed Transcript |
| Official Symbol | STAT2 |
| Official Name | signal transducer and activator of transcription 2 [Source:HGNC Symbol;Acc:HGNC:11363] |
| Ensembl ID | ENSG00000170581 |
| Bio databases IDs | |
| Aliases | signal transducer and activator of transcription 2 |
| Synonyms | 1600010G07Rik,IMD44,ISGF-3,P113,PTORCH3,signal transducer and activator of transcription 2,STAT113 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Signal transducer and activator of transcription 2 C terminal
- transcription regulator
- DNA binding domain
- STAT protein, DNA binding domain
- nuclear localization sequence
- transcription activation domain
- enzyme binding
- coiled-coil domain
- protein binding
- PYTK motif
- identical protein binding
- STAT protein, all-alpha domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- STAT_CCD
- Src homology 2 (SH2) domain
- transcription factor activity
- CBP binding domain
- DNA-binding domain of Signal Transducer and Activator of Transcription (STAT)
- STAT protein, protein interaction domain
Pathways
Biological processes and signaling networks where the STAT2 gene plays a role, providing insight into its function and relevance in health or disease.
- Activation of IRF by Cytosolic Pattern Recognition Receptors
- Dendritic Cell Maturation
- FLT3 Signaling in Hematopoietic Progenitor Cells
- Interferon Signaling
- JAK/Stat Signaling
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of JAK1, JAK2 and TYK2 in Interferon Signaling
- Role of PKR in Interferon Induction and Antiviral Response
- Tec Kinase Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumorigenesis
- Huntington disease
- insulin-dependent diabetes mellitus
- immunodeficiency 44
- psoriatic arthritis
- pseudo-TORCH syndrome type 3
- psoriasis
- T-cell non-Hodgkin disease
- Sjogren syndrome keratoconjunctivitis sicca
- neutropenia
role in cell
- phosphorylation in
- recruitment in
- apoptosis
- expression in
- proliferation
- survival
- activation in
- production in
- colony formation
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- Plasma Membrane
- Golgi Apparatus
- cytosol
- nucleoplasm
- chromatin
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the STAT2 gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- regulation of protein phosphorylation
- negative regulation of type I interferon-mediated signaling pathway
- defense response to virus
- regulation of mitochondrial fission
- defense response
- positive regulation of transcription from RNA polymerase II promoter
- response to peptide hormone stimulus
- regulation of cell proliferation
- regulation of transcription from RNA polymerase II promoter
- JAK-STAT cascade
- type I interferon-mediated signaling pathway
cellular COMPONENT
Where in the cell the gene product is active
- nucleus
- cytoplasm
- ISGF3 complex
- cytosol
- chromatin
- plasma membrane
- nucleoplasm
molecular FUNCTION
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- identical protein binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- small conjugating protein ligase binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity