FOXO4 Gene Summary
This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Details
| Type | Protein Coding |
| Official Symbol | FOXO4 |
| Official Name | forkhead box O4 [Source:HGNC Symbol;Acc:HGNC:7139] |
| Ensembl ID | ENSG00000184481 |
| Bio databases IDs | |
| Aliases | forkhead box O4 |
| Synonyms | AFX,AFX1,Afxh,forkhead box O4,MLLT7,RGD1561201 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- FH_FOX
- transcription activation domain
- transcription factor binding
- chromatin binding
- identical protein binding
- Forkhead domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- Sp1 binding domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- Akt phosphorylation site
- DNA binding domain
- beta-catenin binding
- nucleic acid binding
- Transactivation domain of FOXO protein family
- CR2 domain
- enzyme binding
- CR3 domain
- protein binding
- sequence-specific DNA binding
- DNA binding
- FORKHEAD
- phosphorylation site
- double-stranded DNA binding
- transcription factor activity
Pathways
Biological processes and signaling networks where the FOXO4 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- adenoma formation
- epithelial neoplasia
- benign neoplasia
- hepatic steatosis
- tumorigenesis
- epithelial cancer
- Duchenne muscular dystrophy
- anaplastic thyroid carcinoma
- anaplastic thyroid cancer
role in cell
- phosphorylation in
- accumulation
- apoptosis
- expression in
- proliferation
- cell cycle progression
- growth
- differentiation
- migration
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear speckles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the FOXO4 gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- mitotic cell cycle G2/M transition DNA damage checkpoint
- insulin receptor signaling pathway
- negative regulation of cell proliferation
- regulation of transcription, DNA-dependent
- negative regulation of smooth muscle cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- muscle organ development
- response to oxidative stress
- stem cell differentiation
- positive regulation of smooth muscle cell migration
- negative regulation of G0 to G1 transition
- response to nutrient levels
cellular COMPONENT
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- cytosol
- chromatin
- nucleoplasm
molecular FUNCTION
What the gene product does at the molecular level
- nucleic acid binding
- DNA binding
- sequence-specific DNA binding transcription factor activity
- identical protein binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding
- beta-catenin binding
- enzyme binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity