HRH1 Gene Summary
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2015]
Details
| Type | Protein Coding |
| Official Symbol | HRH1 |
| Official Name | histamine receptor H1 [Source:HGNC Symbol;Acc:HGNC:5182] |
| Ensembl ID | ENSG00000196639 |
| Bio databases IDs | |
| Aliases | histamine receptor H1 |
| Synonyms | Bphs,H1,H1-R,H1 receptor,HH1R,Hir,hisH1,Hisr,Histamine H1,histamine H1 receptor,histamine receptor H 1,HR1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- histamine receptor
- calcium ion transporter
- binding protein
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the HRH1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- relapsed multiple myeloma
- plasma cell myeloma
- major depression
- attention deficit hyperactivity disorder
- diabetes mellitus
- postoperative pain
- relapsing-remitting multiple sclerosis
- non-small cell lung cancer
- substance-related disorder
role in cell
- expression in
- production in
- proliferation
- migration
- differentiation
- neuroprotection
- activation
- growth
- depolarization
- recruitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- cellular membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the HRH1 gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- inflammatory response
- G-protein coupled receptor signaling pathway
- cellular response to histamine
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- positive regulation of vasoconstriction
- regulation of synaptic plasticity
- synaptic transmission
- regulation of vascular permeability
- visual learning
- phospholipase C-activating G-protein coupled receptor signaling pathway
- memory
cellular COMPONENT
Where in the cell the gene product is active
- dendrite
- cytosol
- synapse
- plasma membrane
molecular FUNCTION
What the gene product does at the molecular level
- histamine receptor activity
- neurotransmitter receptor activity
- serotonin receptor activity