NOS1AP Gene Summary [Human]
This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2009]
Details
| Type | Protein Coding |
| Official Symbol | NOS1AP |
| Official Name | nitric oxide synthase 1 adaptor protein [Source:HGNC Symbol;Acc:HGNC:16859] |
| Ensembl ID | ENSG00000198929 |
| Bio databases IDs | |
| Aliases | nitric oxide synthase 1 adaptor protein, C-terminal PDZ domain ligand of neuronal nitric oxide synthase |
| Synonyms | 6330408P19Rik, CAPON, KIAA0464, nitric oxide synthase 1 adaptor protein, nitric oxide synthase 1 (neuronal) adaptor protein, NPHS22 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NOS1AP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- protease binding
- nitric oxide synthase regulator
- neuronal NO synthase binding domain
- protein binding activity, bridging
- enzyme binding
- protein binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
- PDZ-domain binding
Pathways
Biological processes and signaling networks where the NOS1AP gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin resistance
- bipolar disorder
- congenital long QT syndrome
- nephrotic syndrome type 22
- schizophrenia
- ventricular fibrillation
- ventricular extrasystole
- ventricular tachycardia
role in cell
- cell death
- binding in
- formation in
- outgrowth
- formation
- production in
- action potential
- production
- outgrowth in
- generation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- plasma membrane fraction
- glutaminergic synapse
- presynaptic regions
- perinuclear region
- postsynaptic region
- Nucleus
- sarcoplasmic reticulum
- Mitochondria
- cell-cell contacts
- cytosol
- caveolae
- nuclear envelope
- sarcolemma
- Z line
- transverse tubules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NOS1AP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of peptidyl-cysteine S-nitrosylation
- regulation of heart rate by chemical signal
- regulation of nitric-oxide synthase activity
- regulation of ventricular cardiomyocyte membrane repolarization
- nitric oxide biosynthetic process
- regulation of nitric oxide biosynthetic process
Cellular Component
Where in the cell the gene product is active
- podosome
- Z disc
- nucleus
- T-tubule
- nuclear membrane
- caveola
- perinuclear region of cytoplasm
- anchoring junction
- sarcolemma
- mitochondrion
- filopodium
- cytosol
- sarcoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling adaptor activity
- nitric-oxide synthase regulator activity
- nitric-oxide synthase binding