Foxp2 Gene Summary [Mouse]
Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; identical protein binding activity; and transcription coregulator binding activity. Involved in cerebellar Purkinje cell differentiation; gene expression; and vocalization behavior. Acts upstream of or within several processes, including positive regulation of cell population proliferation; righting reflex; and vocal learning. Is active in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; musculoskeletal system; and respiratory system. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; autism spectrum disorder (multiple); communication disorder (multiple); dyslexia; and major depressive disorder. Orthologous to human FOXP2 (forkhead box P2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Foxp2 |
| Official Name | forkhead box P2 [Source:MGI Symbol;Acc:MGI:2148705] |
| Ensembl ID | ENSMUSG00000029563 |
| Bio databases IDs | |
| Aliases | forkhead box P2 |
| Synonyms | 2810043D05Rik, CAG-16, CAGH44, D0Kist7, forkhead box P2, RGD1559697, SPCH1, TNRC10 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Foxp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- FH_FOX
- nucleic acid binding
- androgen receptor binding
- transcription factor binding
- leucine zipper domain
- protein binding
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- Forkhead domain
- FORKHEAD
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- FOXP coiled-coil domain
- double-stranded DNA binding
- protein homodimerization
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- osteoarthritis
- isolated childhood apraxia of speech
- hereditary disorder
- insomnia
- metabolic syndrome X
- post-traumatic stress disorder
- opioid-related disorder
- schizophrenia
phenotypes
- decreased circulating phosphate level
- increased body weight
- abnormal Purkinje cell dendrite morphology
- abnormal cardiovascular system physiology
- abnormal cerebellar Purkinje cell layer
- abnormal cerebellar foliation
- abnormal cerebellum external granule cell layer morphology
- abnormal cerebellum morphology
- abnormal circulating mineral level
- abnormal dendrite morphology
- abnormal eating behavior
- abnormal energy homeostasis
- abnormal long term depression
- abnormal motor capabilities/coordination/movement
- abnormal motor learning
- abnormal neurite morphology
- abnormal radial glial cell morphology
- abnormal reflex
- abnormal respiratory conducting tube morphology
- abnormal response to novel object
- abnormal synaptic plasticity
- abnormal vocalization
- altered righting response
- bradykinesia
- decreased QRS amplitude
- decreased body size
- decreased body weight
- decreased brain size
- decreased dopamine level
- decreased exploration in new environment
- decreased lean body mass
- decreased startle reflex
- decreased total fat pad weight
- decreased vocalization
- delayed ear emergence
- delayed eyelid opening
- embryonic lethality incomplete penetrance
- enhanced paired-pulse facilitation
- hypoactivity
- impaired coordination
- impaired lung alveolus development
- impaired righting response
- increased CD4-positive alpha beta T cell number
- increased CD8-positive alpha-beta T cell number
- increased circulating ferritin level
- increased dopamine level
- increased pulmonary respiratory rate
- increased serotonin level
- overexpanded pulmonary alveoli
- perinatal lethality incomplete penetrance
- positive geotaxis
- postnatal growth retardation
- postnatal lethality complete penetrance
- premature death
- reduced cerebellar foliation
- reduced long term depression
- slow postnatal weight gain
- small cerebellum
- thin cerebellar molecular layer
role in cell
- expression in
- proliferation
- apoptosis
- phosphorylation in
- number
- colony formation by
- growth
- migration
- abnormal morphology
- genesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Foxp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- caudate nucleus development
- putamen development
- cerebral cortex development
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- identical protein binding
- protein homodimerization activity
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity