mRNA & lncRNA Functional Analysis

Our traditional siRNA solutions support a range of loss-of-function experiments, from the knockdown of a single gene of interest, to small numbers of related genes or genes within a common pathway, to genomewide high-throughput screens.

For particularly difficult applications, the Antisense LNA GapmeRs are an excellent alternative to siRNA. For example, many lncRNAs are confined to the nuclear compartment, where they are inefficiently targeted by siRNA. But these lncRNAs remain sensitive to LNA GapmeRs, which function by RNase H-dependent degradation of complementary RNA targets to provide strand-specific knockdown with no RISC-associated, off-target activity. The LNA GapmeRs are active in vivo and in vitro, enabling the analysis RNA function in a wide range of model systems.