EHBP1

EHBP1 Gene Summary

This gene encodes an Eps15 homology domain binding protein. The encoded protein may play a role in endocytic trafficking. A single nucleotide polymorphism in this gene is associated with an aggressive form of prostate cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

Details

Type
Protein Coding
Official Symbol
EHBP1
Official Name
EH domain binding protein 1 [Source:HGNC Symbol;Acc:HGNC:29144]
Ensembl ID
ENSG00000115504
Bio databases IDs NCBI: 23301 Ensembl: ENSG00000115504
Aliases EH domain binding protein 1
Synonyms
AF424697,EH domain binding protein 1,Flj21950,HPC12,KIAA0903,NACSIN,RGD1310604
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • N-terminal C2 in EEIG1 and EHBP1 proteins
  • Calponin homology domain
  • Bivalent Mical/EHBP Rab binding domain
  • NPF motif
  • calponin homology (CH) domain superfamily
  • protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • KDM1A
  • H1-2
  • RHOT2
  • LRRC59
  • CAV1
  • AATK
  • NUP155
  • ZRANB1
  • NDUFS1
  • TRIM25
disease
  • prostatic carcinoma
  • prostate cancer
  • epithelial cancer
  • depressive disorder
  • cleft lip
  • metabolic syndrome X
  • myocardial infarction
  • essential tremor
  • hemorrhoid
  • pervasive developmental disorder
regulated by
  • camptothecin
  • calcitriol
  • SHH
regulates
  • TF
  • EHD2
  • F Actin
role in cell
  • size

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Plasma Membrane
  • cytosol
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the EHBP1 gene, providing context for its role in the cell.

BIOLOGICAL PROCESS

Functions and activities the gene product is involved in
  • protein transport
  • endocytosis

CELLULAR COMPONENT

Where in the cell the gene product is active
  • endosome
  • cytosol
  • plasma membrane
  • nucleoplasm

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.