RFC3 Gene Summary
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kDa. This gene encodes the 38 kDa subunit. This subunit is essential for the interaction between the 140 kDa subunit and the core complex that consists of the 36, 37, and 40 kDa subunits. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | RFC3 |
| Official Name | replication factor C subunit 3 [Source:HGNC Symbol;Acc:HGNC:9971] |
| Ensembl ID | ENSG00000133119 |
| Bio databases IDs | |
| Aliases | replication factor C subunit 3, RFC, 38 kD subunit, A1 38 kDa subunit |
| Synonyms | 2810416I22Rik,p38,RECC3,replication factor C (activator 1) 3,replication factor C subunit 3,RFC,RFC38 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- single-stranded DNA dependent ATP dependent DNA helicase
- LXXLL motif
- DNA polymerase III, delta subunit
- ATP-binding domain
- Rad17 P-loop domain
- enzyme
- protein binding
- DNA dependent ATPase
- DNA binding
- AAA domain
- helical lid domain of clamp loader-like AAA+ proteins
- DNA clamp loader
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Pathways
Biological processes and signaling networks where the RFC3 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- mammary neoplasm
- small cell lung cancer
- cervical small cell carcinoma
- extrapulmonary small cell cancer
- epithelial uterine cancer
- cervical cancer
role in cell
- production in
- proliferation
- binding in
- processing in
- homologous recombination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the RFC3 gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- DNA repair
- DNA strand elongation involved in DNA replication
- DNA replication
- DNA duplex unwinding
- DNA-dependent DNA replication
- response to organophosphorus
- positive regulation of DNA-directed DNA polymerase activity
- DNA synthesis involved in DNA repair
cellular COMPONENT
Where in the cell the gene product is active
- Ctf18 RFC-like complex
- nucleus
- DNA replication factor C complex
- nucleoplasm
molecular FUNCTION
What the gene product does at the molecular level
- ATPase activity
- DNA binding
- DNA clamp loader activity
- DNA-dependent ATPase activity
- protein binding
- single-stranded DNA-dependent ATP-dependent DNA helicase activity