VCAM1 Gene Summary
This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]
Details
| Type | Protein Coding |
| Official Symbol | VCAM1 |
| Official Name | vascular cell adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:12663] |
| Ensembl ID | ENSG00000162692 |
| Bio databases IDs | |
| Aliases | vascular cell adhesion molecule 1 |
| Synonyms | CD106,INCAM-100,LOC100912479,vascular cell adhesion molecule 1,VCAM,VCAM1B,VECAM1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- amine oxidase
- immunoglobulin domain
- cell adhesion molecule binding
- ectodomain
- Immunoglobulin I-set domain
- T-cell surface glycoprotein CD3 delta chain
- cytoplasmic domain
- integrin binding
- transmembrane domain
- Immunoglobulin like
- immunoglobulin-like protein domain
- cytosolic tail domain
- transmembrane receptor
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the VCAM1 gene plays a role, providing insight into its function and relevance in health or disease.
- Agranulocyte Adhesion and Diapedesis
- Apelin Endothelial Signaling Pathway
- Atherosclerosis Signaling
- Glucocorticoid Receptor Signaling
- Granulocyte Adhesion and Diapedesis
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- HMGB1 Signaling
- IL-17A Signaling in Fibroblasts
- IL-8 Signaling
- Leukocyte Extravasation Signaling
- Lymphotoxin β Receptor Signaling
- Neuroinflammation Signaling Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- experimental autoimmune encephalomyelitis
- adenoma formation
- COVID-19
- insulin-dependent diabetes mellitus
- metastasis
- nasal type extranodal NK-/T-cell lymphoma
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- natural killer cell neoplasia
role in cell
- cell death
- cell viability
- respiratory burst
- activation in
- survival
- differentiation
- myogenesis
- activation
- proliferation
- activity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- docking structure
- Cytoplasm
- cell surface
- Extracellular Space
- cell periphery
- apical compartment
- cellular membrane
- podosomes
- Golgi Apparatus
- Endoplasmic Reticulum
- cell-cell contacts
- apical cell surfaces
- vesicle membrane
- plasma membrane extracellular face
- apical membrane
- sarcolemma
- early endosomes
- microvilli
- filopodia
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the VCAM1 gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- response to zinc ion
- innervation
- heterophilic cell-cell adhesion
- cell adhesion
- cardiac neuron differentiation
- leukocyte cell-cell adhesion
- cell chemotaxis
- response to ethanol
- inflammatory response
- amine metabolic process
- response to hypoxia
- cell-cell adhesion mediated by integrin
- cellular response to tumor necrosis factor
- response to ionizing radiation
- cell-matrix adhesion
- B cell differentiation
- response to nutrient
- response to nicotine
- positive regulation of T cell proliferation
- membrane to membrane docking
- chronic inflammatory response
- response to lipopolysaccharide
- cellular response to vascular endothelial growth factor stimulus
- heterotypic cell-cell adhesion
- leukocyte tethering or rolling
cellular COMPONENT
Where in the cell the gene product is active
- external side of plasma membrane
- Golgi apparatus
- endoplasmic reticulum
- plasma membrane
- cell surface
- podosome
- alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex
- extracellular space
- early endosome
- extracellular vesicular exosome
- apical part of cell
- microvillus
- sarcolemma
- filopodium
molecular FUNCTION
What the gene product does at the molecular level
- primary amine oxidase activity
- cell adhesion molecule binding
- integrin binding