Igf2r Gene Summary [Mouse]
Enables D-mannose binding activity and insulin-like growth factor binding activity. Predicted to be involved in several processes, including liver development; positive regulation by host of viral process; and response to retinoic acid. Located in membrane and nuclear envelope lumen. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; early conceptus; and genitourinary system. Human ortholog(s) of this gene implicated in diabetes mellitus (multiple); hepatocellular carcinoma; in situ carcinoma (multiple); and nephroblastoma. Orthologous to human IGF2R (insulin like growth factor 2 receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Igf2r |
| Official Name | insulin-like growth factor 2 receptor [Source:MGI Symbol;Acc:MGI:96435] |
| Ensembl ID | ENSMUSG00000023830 |
| Bio databases IDs | |
| Aliases | insulin-like growth factor 2 receptor |
| Synonyms | AI661837, CD222, CI-M6PR, CI-MPR, IGF-IIR, Igfr2, insulin-like growth factor 2 receptor, M6P/IGF2R, M6P-R, MANNOSE-6-PHOSPHATE receptor, MPR1, MPR 300, MPRI, type 2 IGF receptor, Type 2 insulin-like growth factor receptor, Type II IGF Receptor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Igf2r often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- IGF-binding site
- protein repeat
- acidic-cluster dileucine motif
- phosphoprotein binding
- signal peptide
- insulin-like growth factor binding
- retinoid binding
- identical protein binding
- mannose binding
- cytoplasmic domain
- Cation-independent mannose-6-phosphate receptor repeat
- intracellular domain
- tail domain
- transmembrane receptor
- extracellular domain
- signaling receptor activity
- enzyme binding
- protein binding
- FN2
- binding protein
- insulin-like growth factor receptor
- transmembrane/cytoplasmic domain
- lumenal domain
- transmembrane domain
- cytosolic tail domain
- extracytoplasmic repeat
Pathways
Biological processes and signaling networks where the Igf2r gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- premature ovarian failure
- coronary artery disease
- late onset glycogen storage disease type II
- hyperplasia
- hepatocellular carcinoma
- cyanosis
- weight gain
- cancer
- gait disturbance
- multiple sclerosis
phenotypes
- abnormal body water content
- abnormal bone ossification
- abnormal circulating hormone level
- abnormal craniofacial morphology
- abnormal embryonic growth/weight/body size
- abnormal external female genitalia morphology
- abnormal interventricular septum morphology
- abnormal lung development
- abnormal lung morphology
- abnormal lysosome physiology
- abnormal motor capabilities/coordination/movement
- abnormal myocardium layer morphology
- abnormal tricuspid valve morphology
- abnormal uterine horn morphology
- abnormal uterus morphology
- absent endometrial glands
- absent suckling reflex
- congestive heart failure
- cyanosis
- decreased fetal weight
- decreased litter size
- decreased survivor rate
- dilated heart
- dilated heart left ventricle
- dilated heart right ventricle
- dilated uterine horn
- disorganized myocardium
- edema
- enlarged heart
- enlarged kidney
- enlarged liver
- enlarged lung
- enlarged placenta
- enlarged uterine horn
- enlarged uterus
- female infertility
- genetic imprinting
- heart hemorrhage
- heart hyperplasia
- impaired branching involved in preterminal bronchiole morphogenesis
- increased birth body size
- increased birth weight
- increased body size
- increased body weight
- increased brain size
- increased embryo size
- increased fetal size
- increased fetal weight
- increased heart right ventricle size
- increased heart ventricle size
- increased heart weight
- increased nucleated erythrocyte cell number
- increased placenta weight
- kinked tail
- lethality throughout fetal growth and development incomplete penetrance
- liver hyperplasia
- maternal imprinting
- neonatal lethality complete penetrance
- neonatal lethality incomplete penetrance
- perinatal lethality incomplete penetrance
- polydactyly
- postnatal lethality complete penetrance
- postnatal lethality incomplete penetrance
- premature bone ossification
- prenatal lethality complete penetrance
- preweaning lethality incomplete penetrance
- pulmonary hyperplasia
- reduced female fertility
- reduced male fertility
- respiratory distress
- respiratory failure
- short sternum
- short tail
- split sternum
- thick interventricular septum
- thick ventricular wall
- thin endometrium
- vagina atresia
role in cell
- retention in
- cell death
- cell viability
- apoptosis
- expression in
- proliferation
- transactivation in
- activation in
- migration
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- endosomal fractions
- tubule vesicle fraction
- pH resistant lipid raft fraction
- early endosome-associated tubule
- endocytic vesicle membrane
- Cytoplasm
- perinuclear Golgi regions
- cell surface
- cell borders
- Extracellular Space
- cell periphery
- perinuclear region
- cellular membrane
- Nucleus
- endosomes
- vesicles
- centrosome
- lysosome
- Golgi Apparatus
- secretory granule membrane
- cytoplasmic aggregates
- MHC class II compartments
- trans Golgi network
- lysosome membrane
- endosomal compartment
- endosomal membrane
- perinuclear space
- recycling endosomes
- early endosomes
- late endosomes
- transport vesicles
- endocytotic vesicle
- GLUT4 vesicles
- peripheral vesicles
- microsomal membrane
- clathrin-coated pits
- perikaryon
- clathrin-coated vesicles
- plasma
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Igf2r gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to retinoic acid
- G-protein coupled receptor signaling pathway
- signal transduction
- lysosomal transport
- liver development
- spermatogenesis
- post-embryonic development
- positive regulation of apoptotic process
- insulin-like growth factor receptor signaling pathway
- organ regeneration
- receptor-mediated endocytosis
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network transport vesicle
- late endosome
- Golgi apparatus
- Golgi membrane
- nuclear envelope lumen
- plasma membrane
- cell surface
- clathrin coat
- secretory granule membrane
- endocytic vesicle
- trans-Golgi network
- early endosome
- perinuclear region of cytoplasm
- endosome
- extracellular vesicular exosome
- clathrin-coated endocytic vesicle membrane
- focal adhesion
- membrane
- endosome membrane
- transport vesicle
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- retinoic acid binding
- identical protein binding
- mannose binding
- protein binding
- G-protein alpha-subunit binding
- signaling receptor activity
- insulin-like growth factor-activated receptor activity
- phosphoprotein binding
- insulin-like growth factor binding
- enzyme binding
- insulin-like growth factor II binding