Pdx1 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in positive regulation of insulin secretion and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including digestive system development; negative regulation of apoptotic process; and regulation of DNA-templated transcription. Located in nuclear speck. Is expressed in several structures, including genitourinary system; gut; liver and biliary system; sensory organ; and skeleton. Used to study maturity-onset diabetes of the young; maturity-onset diabetes of the young type 4; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in cerebral infarction; hyperglycemia; maturity-onset diabetes of the young type 4; pancreatic agenesis 1; and type 2 diabetes mellitus. Orthologous to human PDX1 (pancreatic and duodenal homeobox 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pdx1 |
| Official Name | pancreatic and duodenal homeobox 1 [Source:MGI Symbol;Acc:MGI:102851] |
| Ensembl ID | ENSMUSG00000029644 |
| Bio databases IDs | |
| Aliases | pancreatic and duodenal homeobox 1 |
| Synonyms | GSF, Gstf, IDX-1, IPF-1, IPF2, IUF1, MODY4, PAGEN1, pancreatic and duodenal homeobox 1, STF-1, β-TF1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pdx1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- transcription regulator
- nucleic acid binding
- transcription activation domain
- transcription factor binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- binding protein
- double-stranded DNA binding
- heterodimerization domain
- Pka phosphorylation site
- homeodomain
- transcription factor activity
Pathways
Biological processes and signaling networks where the Pdx1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperplasia
- susceptibility to type 2 diabetes mellitus
- colorectal cancer
- morbid obesity
- congenital pancreatic agenesis
- gastric ulcer
- rectal adenocarcinoma
- colorectal carcinomagenesis
- rectum cancer
- growth failure
phenotypes
- abnormal embryo size
- abnormal placenta size
- decreased bone mineral density
- impaired glucose tolerance
- pallor
- preweaning lethality complete penetrance
- abnormal PP cell morphology
- abnormal bile duct development
- abnormal duodenum morphology
- abnormal enteroendocrine cell morphology
- abnormal foregut morphology
- abnormal intestine morphology
- abnormal liver development
- abnormal mitochondrial physiology
- abnormal pancreas development
- abnormal pancreatic acinar cell morphology
- abnormal pancreatic beta cell apoptosis
- abnormal pancreatic beta cell differentiation
- abnormal pancreatic beta cell physiology
- abnormal pancreatic delta cell morphology
- abnormal pancreatic duct morphology
- abnormal pancreatic endocrine progenitor cell physiology
- abnormal pancreatic epsilon cell morphology
- abnormal pancreatic islet cell apoptosis
- abnormal pancreatic islet morphology
- abnormal pancreatic islet size
- abnormal pyloric sphincter morphology
- abnormal small intestine morphology
- abnormal small intestine placement
- abnormal stomach enteroendocrine cell morphology
- abnormal stomach morphology
- abnormal stomach pyloric region morphology
- abnormal tricarboxylic acid cycle
- absent Brunner's glands
- absent pancreas
- decreased amylin secretion
- decreased body size
- decreased body weight
- decreased circulating insulin level
- decreased insulin secretion
- decreased pancreas weight
- decreased pancreatic alpha cell mass
- decreased pancreatic beta cell mass
- decreased pancreatic beta cell number
- decreased pancreatic islet number
- dehydration
- disorganized pancreatic islets
- distended stomach
- exocrine pancreatic insufficiency
- hyperglycemia
- increased PP cell number
- increased circulating glucose level
- increased glucagon secretion
- increased pancreatic alpha cell number
- increased pancreatic beta cell apoptosis
- no abnormal phenotype detected
- pancreas hypoplasia
- pancreas inflammation
- pancreatic islet hypoplasia
- postnatal growth retardation
- postnatal lethality complete penetrance
- small pancreas
- small pancreatic islets
- sparse hair
- thin skin
role in cell
- splicing in
- cell viability
- expression in
- apoptosis
- number
- quantity
- cell death
- function
- proliferation
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular space
- cytosol
- nucleoplasm
- nuclear rim
- nuclear speckles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pdx1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- insulin secretion
- response to iron(II) ion
- transcription from RNA polymerase II promoter
- type B pancreatic cell apoptotic process
- response to leucine
- response to xenobiotic stimulus
- glucose metabolic process
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- stem cell differentiation
- digestive tract development
- type B pancreatic cell proliferation
- liver development
- type B pancreatic cell differentiation
- response to glucocorticoid stimulus
- negative regulation of type B pancreatic cell apoptotic process
- transdifferentiation
- morphogenesis of embryonic epithelium
- response to fatty acid
- positive regulation of insulin secretion
- glucose mediated signaling pathway
- exocrine pancreas development
- positive regulation of insulin secretion involved in cellular response to glucose stimulus
- response to chlorate
- generation of precursor metabolites and energy
- response to vitamin
- smoothened signaling pathway
- response to alkaloid
- response to nicotine
- regulation of transcription from RNA polymerase II promoter
- organ morphogenesis
- negative regulation of epithelial cell proliferation
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
- organ regeneration
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity