Cux1 Gene Summary [Mouse]
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and chromatin binding activity. Involved in positive regulation of dendrite morphogenesis. Acts upstream of or within several processes, including inner ear auditory receptor cell differentiation; lung development; and negative regulation of transcription by RNA polymerase II. Located in cytoplasm; neuron projection; and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human CUX1 (cut like homeobox 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cux1 |
| Official Name | cut-like homeobox 1 [Source:MGI Symbol;Acc:MGI:88568] |
| Ensembl ID | ENSMUSG00000029705 |
| Bio databases IDs | |
| Aliases | cut-like homeobox 1 |
| Synonyms | CASP, CDP, CDP1, CDP2, CDP/Cut, Cdp/cux, Clox, COY1, CUT, CUTL1, cut-like homeobox 1, CUX, Cux/CDP, GDDI, GOLIM6, LOC100506550, Nbla10317 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cux1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- Nuf2, DHR10-like domain
- WTAP/Mum2p family
- transcription regulator
- B-Box C-terminal domain
- Afadin- and alpha -actinin-Binding
- protein binding activity, bridging
- cyclin recognition motif
- coiled-coil domain
- chromatin binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- Tropomyosin
- CASP C terminal
- homeodomain
- HOOK protein coiled-coil region
- DNA binding domain
- nucleic acid binding
- CR1 domain
- CR2 domain
- CR3 domain
- SWI5-dependent HO expression protein 3
- protein binding
- sequence-specific DNA binding
- DNA binding
- Mechanosensitive ion channel porin domain
- CUT domain
- double-stranded DNA binding
- Growth-arrest specific micro-tubule binding
- ClyA-like
- Intermediate filament protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- prostate cancer
- epithelial cancer
- epithelial neoplasia
- cancer
- headache
- global developmental delay with or without impaired intellectual development
- organismal death
- mixed neoplasia
phenotypes
- abnormal T cell differentiation
- abnormal alveolocapillary membrane morphology
- abnormal bone structure
- abnormal coat/ hair morphology
- abnormal hair follicle morphology
- abnormal hair follicle orientation
- abnormal hair shaft morphology
- abnormal lung development
- abnormal lung morphology
- abnormal maternal behavior
- abnormal myelopoiesis
- abnormal pulmonary alveolar duct morphology
- abnormal tumor necrosis factor level
- absent auchene hairs
- absent awl hair
- absent guard hair
- absent hair follicle inner root sheath
- absent zigzag hairs
- alopecia
- cachexia
- curly vibrissae
- cyanosis
- darkened coat color
- decreased B cell number
- decreased body size
- decreased circulating testosterone level
- decreased double-positive T cell number
- decreased thymocyte number
- decreased total body fat amount
- enlarged hair follicles
- increased hair follicle number
- increased susceptibility to bacterial infection
- kinked vibrissae
- neonatal lethality incomplete penetrance
- postnatal growth retardation
- postnatal lethality
- postnatal lethality incomplete penetrance
- premature death
- reduced fertility
- reduced male fertility
- respiratory failure
- rhinitis
- short vibrissae
- small thymus
- sparse hair
- thymus cortex hypoplasia
- thymus hypoplasia
- wavy vibrissae
role in cell
- apoptosis
- expression in
- growth
- phosphorylation in
- differentiation
- invasion by
- proliferation
- activation in
- activity
- length
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- Golgi Apparatus
- cytosol
- Golgi membrane
- nucleoplasm
- neurites
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cux1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- intra-Golgi vesicle-mediated transport
- positive regulation of dendrite morphogenesis
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- Golgi apparatus
- Golgi membrane
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity