Ins1 Gene Summary [Rat]
Enables insulin receptor binding activity. Involved in several processes, including cellular response to glucose stimulus; response to cAMP; and response to dimethyl sulfoxide. Located in extracellular space. Biomarker of Alzheimer's disease. Human ortholog(s) of this gene implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Orthologous to several human genes including INS (insulin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ins1 |
| Official Name | insulin 1 [Source:RGD Symbol;Acc:2915] |
| Ensembl ID | ENSRNOG00000012052 |
| Bio databases IDs | |
| Aliases | insulin 1 |
| Synonyms | Ins2-rs1, insulin 1, Insulin I, Preproinsulin, proinsulin, proinsulin-1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ins1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta strand or sheet
- transmembrane receptor protein tyrosine kinase activator
- insulin receptor binding
- protease binding
- Insulin/IGF/Relaxin family
- IlGF_like
- receptor agonist activity
- hormone
- identical protein binding
- insulin-like growth factor receptor binding
Pathways
Biological processes and signaling networks where the Ins1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- AMPK Signaling
- Apelin Adipocyte Signaling Pathway
- Apelin Pancreas Signaling Pathway
- Autophagy
- EIF2 Signaling
- FXR/RXR Activation
- G Protein Signaling Mediated by Tubby
- Hepatic Cholestasis
- Insulin Receptor Signaling
- Maturity Onset Diabetes of Young (MODY) Signaling
- mTOR Signaling
- NF-κB Signaling
- PPAR Signaling
- PPARα/RXRα Activation
- PXR/RXR Activation
- Role of JAK2 in Hormone-like Cytokine Signaling
- Thyroid Cancer Signaling
- Transcriptional Regulatory Network in Embryonic Stem Cells
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin-dependent diabetes mellitus
- ketoacidosis
- anaphylaxis
role in cell
- quantity
- number
- mass
- mitogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- detergent-soluble membrane fractions
- secretory granule lumen
- Cytoplasm
- cell surface
- intracellular space
- perinuclear region
- Nucleus
- Plasma Membrane
- vesicles
- cytoplasmic particles
- granules
- cytosol
- olfactory cilia
- endoplasmic reticulum lumen
- insulin secretory granules
- Weibel-Palade bodies
- secretory granules
- plasma