PRSS3 Gene Summary

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2010]

Details

Type
Processed Transcript
Official Symbol
PRSS3
Official Name
serine protease 3 [Source:HGNC Symbol;Acc:HGNC:9486]
Ensembl ID
ENSG00000010438
Bio databases IDs NCBI: 5646 Ensembl: ENSG00000010438
Aliases serine protease 3, mesotrypsin
Synonyms
mesotrypsin,MESOTRYPSINOGEN,MTG,PRSS4,serine protease 3,T9,TRY3,TRY4
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Trypsin-like serine protease
  • serine endopeptidase
  • trypsin
  • Tryp_SPc
  • serine-type peptidase
  • peptidase
  • calcium ion binding
  • protein binding

Pathways

Biological processes and signaling networks where the PRSS3 gene plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • edema
  • mechanical hyperalgesia
  • psoriasis
  • heat hyperalgesia
  • epidermal hyperplasia
  • autoimmune pancreatitis
regulated by
  • TGFB1
  • RAF1
  • MYOC
  • taurochenodeoxycholate
  • glycochenodeoxycholate
  • taurocholic acid
  • glycocholic acid
  • glycodeoxycholic acid
  • taurodeoxycholic acid
  • LGALS3
regulates
role in cell
  • migration
  • growth
  • cellular infiltration by
  • desensitization
  • replication in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space
  • organelle lumens
  • plasma

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the PRSS3 gene, providing context for its role in the cell.

biological PROCESS

Functions and activities the gene product is involved in
  • zymogen activation
  • proteolysis
  • digestion
  • antimicrobial humoral response
  • endothelial cell migration

cellular COMPONENT

Where in the cell the gene product is active
  • extracellular space
  • extracellular region

molecular FUNCTION

What the gene product does at the molecular level
  • protein binding
  • calcium ion binding
  • serine-type peptidase activity
  • serine-type endopeptidase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.