TNFRSF9 Gene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TNFRSF9 |
| Official Name | TNF receptor superfamily member 9 [Source:HGNC Symbol;Acc:HGNC:11924] |
| Ensembl ID | ENSG00000049249 |
| Bio databases IDs | |
| Aliases | TNF receptor superfamily member 9 |
| Synonyms | 4-1BB,A930040I11RIK,CD137,CDw137,ILA,IMD109,Ly63,TNF receptor superfamily member 9,tumor necrosis factor receptor superfamily, member 9,tumour necrosis factor receptor superfamily, member 9 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- traf2 binding domain
- laminin homology domain
- signaling receptor activity
- costimulatory domain
- intracellular domain
- TNFR/NGFR cysteine-rich region
- protein binding
- Cys-x-cys-pro motif
- Tumor necrosis factor receptor superfamily (TNFRSF)
- transmembrane receptor
Pathways
Biological processes and signaling networks where the TNFRSF9 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diffuse large B-cell lymphoma
- neoplasia
- atherosclerosis
- proteinuria
- insulin-dependent diabetes mellitus
- high-grade B-cell lymphoma
- cancer
- solid tumor
- breast cancer
- hepatomegaly
role in cell
- growth
- cell death
- expression in
- production in
- apoptosis
- cellular infiltration by
- proliferation
- activation in
- survival
- upregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the TNFRSF9 gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- regulation of immature T cell proliferation in thymus
- negative regulation of cell proliferation
- apoptotic process
- regulation of cell proliferation
cellular COMPONENT
Where in the cell the gene product is active
- external side of plasma membrane
- plasma membrane
molecular FUNCTION
What the gene product does at the molecular level
- protein binding
- signaling receptor activity