PIN1 Gene Summary
Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]
Details
| Type | Processed Transcript |
| Official Symbol | PIN1 |
| Official Name | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [Source:HGNC Symbol;Acc:HGNC:8988] |
| Ensembl ID | ENSG00000127445 |
| Bio databases IDs | |
| Aliases | peptidylprolyl cis/trans isomerase, NIMA-interacting 1, protein interacting with never in mitosis A1, parvulin PIN1 |
| Synonyms | 0610025L01Rik,D9Bwg1161e,DOD,peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1,UBL5 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- beta-catenin binding
- catalytic domain
- peptidylprolyl isomerase
- phosphoprotein binding
- enzyme
- enzyme regulator activity
- protein binding
- enzyme activator activity
- WW domain
- phosphoprotein amino acid binding
- Domain with 2 conserved Trp (W) residues
- Cis-trans isomerase
- WW
- PPIC-type PPIASE domain
- motor protein
Pathways
Biological processes and signaling networks where the PIN1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- obesity
- tauopathy
- tumorigenesis
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- nonalcoholic steatohepatitis
- impaired glucose tolerance
role in cell
- activation in
- phosphorylation in
- expression in
- cell viability
- apoptosis
- degradation in
- proliferation
- replication in
- formation
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- membrane fraction
- glutaminergic synapse
- Cytoplasm
- basal bodies
- centrosome
- midbody
- cytosol
- nucleoplasm
- nuclear speckles
- neurites
- perikaryon
- axons
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the PIN1 gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- positive regulation of protein binding
- negative regulation of protein catabolic process
- protein peptidyl-prolyl isomerization
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of protein binding
- positive regulation of GTPase activity
- response to hypoxia
- regulation of cytokinesis
- negative regulation of SMAD protein import into nucleus
- synapse organization
- regulation of mitosis
- neuron differentiation
- positive regulation of canonical Wnt receptor signaling pathway
- microtubule polymerization
- regulation of protein stability
- regulation of protein phosphorylation
- negative regulation of ERK1 and ERK2 cascade
- positive regulation of protein phosphorylation
- regulation of gene expression
- negative regulation of cell motility
- positive regulation of protein dephosphorylation
- protein stabilization
- negative regulation of transforming growth factor beta receptor signaling pathway
- regulation of protein localization to nucleus
cellular COMPONENT
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cilium basal body
- nuclear speck
- cytosol
- midbody
- nucleoplasm
molecular FUNCTION
What the gene product does at the molecular level
- peptidyl-prolyl cis-trans isomerase activity
- protein binding
- cis-trans isomerase activity
- phosphothreonine binding
- tau protein binding
- phosphoserine binding
- phosphoprotein binding
- GTPase activating protein binding
- beta-catenin binding
- motor activity
- mitogen-activated protein kinase kinase binding