SNRPG Gene Summary

The protein encoded by this gene is a component of the U1, U2, U4, and U5 small nuclear ribonucleoprotein complexes, precursors of the spliceosome. The encoded protein may also be a part of the U7 small nuclear ribonucleoprotein complex, which participates in the processing of the 3' end of histone transcripts. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Details

Type
Protein Coding
Official Symbol
SNRPG
Official Name
small nuclear ribonucleoprotein polypeptide G [Source:HGNC Symbol;Acc:HGNC:11163]
Ensembl ID
ENSG00000143977
Bio databases IDs NCBI: 6637 Ensembl: ENSG00000143977
Aliases small nuclear ribonucleoprotein polypeptide G
Synonyms
2810024K17Rik,AL022803,D15Mgi25,LOC686174,small nuclear ribonucleoprotein polypeptide G,SMG,snRNP-G
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Sm and related proteins
  • ribonucleoprotein binding
  • protein binding

Pathways

Biological processes and signaling networks where the SNRPG gene plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • peripheral arterial disease
  • non-small cell lung cancer
  • chronic kidney disease
  • renal cell carcinoma
  • renal cell cancer
regulated by
  • dexamethasone
  • ESR2
  • imatinib
  • poly rI:rC-RNA
  • doxifluridine
  • HRAS
  • DAP3
  • ST1926
  • tanespimycin
  • Major late
regulates
role in cell
  • cell viability
  • apoptosis
  • cell death
  • splicing by
  • alternative splicing in
  • maturation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • nuclear fraction
  • catalytic step 2 spliceosome
  • cytosol
  • spliceosomes
  • nucleoplasm
  • interchromatin granule clusters

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the SNRPG gene, providing context for its role in the cell.

biological PROCESS

Functions and activities the gene product is involved in
  • RNA splicing
  • spliceosomal complex assembly
  • nuclear mRNA splicing, via spliceosome
  • spliceosomal snRNP assembly

cellular COMPONENT

Where in the cell the gene product is active
  • U5 snRNP
  • spliceosomal complex
  • U2-type spliceosomal complex
  • U7 snRNP
  • U2 snRNP
  • U1 snRNP
  • nucleoplasm
  • U4 snRNP
  • U12-type spliceosomal complex
  • nucleus
  • catalytic step 2 spliceosome
  • methylosome
  • precatalytic spliceosome
  • U4/U6 x U5 tri-snRNP complex
  • P granule
  • SMN-Sm protein complex
  • cytosol
  • U2-type catalytic step 2 spliceosome
  • U2-type prespliceosome
  • U2-type precatalytic spliceosome
  • small nuclear ribonucleoprotein complex

molecular FUNCTION

What the gene product does at the molecular level
  • protein binding
  • RNA binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.