Tnfsf11 Gene Summary [Mouse]
Enables identical protein binding activity; receptor ligand activity; and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including intracellular signaling cassette; positive regulation of secretion by cell; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including cellular response to cytokine stimulus; mammary gland development; and positive regulation of intracellular signal transduction. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in extracellular space. Is expressed in bone; genitourinary system; hemolymphoid system; incisor; and rib. Used to study autosomal recessive osteopetrosis 2 and osteoporosis. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 2 and osteoporosis. Orthologous to human TNFSF11 (TNF superfamily member 11). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnfsf11 |
| Official Name | tumor necrosis factor (ligand) superfamily, member 11 [Source:MGI Symbol;Acc:MGI:1100089] |
| Ensembl ID | ENSMUSG00000022015 |
| Bio databases IDs | |
| Aliases | tumor necrosis factor (ligand) superfamily, member 11 |
| Synonyms | CD254, hRANKL2, LOC103689974, Ly109l, ODF, OPGL, OPTB2, RANKL, Rankl1, sOdf, TNF superfamily member 11, TNLG6B, TRANCE, tumor necrosis factor (ligand) superfamily, member 11, tumour necrosis factor (ligand) superfamily, member 11, tumour necrosis factor related activation induced cytokine |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tnfsf11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- TNF homology domain
- TNF
- ectodomain
- protein binding
- cytokine
- identical protein binding
- hematopoietin/interferon-class (D200-domain) cytokine receptor ligand
- receptor binding domain
- cytoplasmic domain
- transmembrane domain
- receptor agonist activity
- membrane-proximal domain
Pathways
Biological processes and signaling networks where the Tnfsf11 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
- Erythropoietin Signaling
- Hepatic Cholestasis
- HMGB1 Signaling
- IL-17 Signaling
- NF-κB Signaling
- RANK Signaling in Osteoclasts
- RAR Activation
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Th1 and Th2 Activation Pathway
- Th1 Pathway
- VDR/RXR Activation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- HIV infection
- metastasis
- infection
- pain
- cancer
- nodal marginal zone lymphoma
- chronic lymphocytic leukemia / small lymphocytic lymphoma
- extranodal marginal zone cell lymphoma
- osteopenia
phenotypes
- abnormal areal bone mineral density
- abnormal bone marrow morphology
- abnormal cartilage morphology
- abnormal cervical lymph node morphology
- abnormal chondrocyte differentiation
- abnormal chondrocyte morphology
- abnormal cranial suture morphology
- abnormal craniofacial bone morphology
- abnormal hyoid bone body morphology
- abnormal immune system morphology
- abnormal immune system physiology
- abnormal long bone epiphyseal plate morphology
- abnormal long bone epiphyseal plate proliferative zone
- abnormal long bone internal diameter
- abnormal long bone metaphysis morphology
- abnormal lung morphology
- abnormal mammary gland growth during pregnancy
- abnormal maternal nurturing
- abnormal neurocranium morphology
- abnormal osteoblast physiology
- abnormal pelvic girdle bone morphology
- abnormal pro-B cell differentiation
- abnormal spleen B cell follicle morphology
- abnormal spleen marginal zone morphology
- abnormal spleen morphology
- abnormal splenic cell ratio
- abnormal tail length
- abnormal thymus cell ratio
- abnormal thymus epithelium morphology
- abnormal trabecular bone morphology
- abnormal zygomatic bone morphology
- absent cervical lymph nodes
- absent lymph nodes
- absent mesenteric lymph nodes
- absent peripheral lymph nodes
- arrested T cell differentiation
- decreased Langerhans cell number
- decreased Peyer's patch number
- decreased body size
- decreased body weight
- decreased bone marrow cell number
- decreased bone mineral density
- decreased bone resorption
- decreased bone trabecula number
- decreased circulating calcium level
- decreased cranium height
- decreased immature B cell number
- decreased interferon-gamma secretion
- decreased interleukin-2 secretion
- decreased interleukin-4 secretion
- decreased interleukin-5 secretion
- decreased interleukin-6 secretion
- decreased internal diameter of femur
- decreased lean body mass
- decreased length of long bones
- decreased mature B cell number
- decreased osteoclast cell number
- decreased spleen white pulp amount
- decreased thymus weight
- dystrophic muscle
- enlarged spleen
- extramedullary hematopoiesis
- failure of tooth eruption
- increased areal bone mineral density
- increased bone mass
- increased bone mineral content
- increased bone mineral density
- increased bone mineralization
- increased bone trabecula number
- increased bone volume
- increased diameter of long bones
- increased diameter of tibia
- increased long bone epiphyseal plate size
- increased spleen red pulp amount
- increased spleen weight
- increased trabecular bone thickness
- increased width of hypertrophic chondrocyte zone
- kyphosis
- lactation failure
- macrocytic anemia
- mandible hypoplasia
- optic canal stenosis
- osteopetrosis
- postnatal growth retardation
- premature death
- reduced fertility
- round face
- short tibia
- short vertebral column
- small Peyer's patches
- small cranium
- small thymus medulla
- supernumerary teeth
- thin neurocranium
- thymus hypoplasia
role in cell
- phosphorylation in
- proliferation
- production in
- expression in
- induction in
- invasion by
- cell death
- cell viability
- degradation in
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- intracellular space
- cellular membrane
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- extracellular matrix
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tnfsf11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- osteoclast development
- calcium ion homeostasis
- positive regulation of homotypic cell-cell adhesion
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- JNK cascade
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of NF-kappaB transcription factor activity
- negative regulation of transcription from RNA polymerase II promoter
- osteoclast proliferation
- positive regulation of corticotropin-releasing hormone secretion
- protein kinase B signaling cascade
- positive regulation of T cell activation
- immune response
- positive regulation of osteoclast differentiation
- mammary gland alveolus development
- bone resorption
- ossification
- cytokine-mediated signaling pathway
- mammary gland epithelial cell proliferation
- positive regulation of osteoclast development
- calcium-mediated signaling
- positive regulation of fever generation by positive regulation of prostaglandin secretion
- paracrine signaling
- ERK1 and ERK2 cascade
- osteoclast differentiation
- tumor necrosis factor-mediated signaling pathway
- monocyte chemotaxis
- positive regulation of bone resorption
- positive regulation of JNK cascade
- positive regulation of gene expression
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- tumor necrosis factor receptor superfamily binding
- protein binding
- tumor necrosis factor receptor binding
- cytokine activity