Inpp5d Gene Summary [Mouse]
Predicted to enable inositol-4,5-bisphosphate 5-phosphatase activity. Acts upstream of or within several processes, including determination of adult lifespan; negative regulation of B cell proliferation; and regulation of hemopoiesis. Predicted to be located in actin filament and cortical cytoskeleton. Predicted to be active in cytosol. Is expressed in several structures, including integumental system; nervous system; respiratory system; skeleton; and spleen. Used to study Paget's disease of bone and systemic lupus erythematosus. Orthologous to human INPP5D (inositol polyphosphate-5-phosphatase D). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Inpp5d |
| Official Name | inositol polyphosphate-5-phosphatase D [Source:MGI Symbol;Acc:MGI:107357] |
| Ensembl ID | ENSMUSG00000026288 |
| Bio databases IDs | |
| Aliases | inositol polyphosphate-5-phosphatase D |
| Synonyms | hp51CN, inositol polyphosphate-5-phosphatase D, p150Ship, SHIP, SHIP-1, SIP-145, s-SHIP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Inpp5d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- inositol-4,5-bisphosphate 5-phosphatase
- phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
- catalytic domain
- SAM domain
- inositol-polyphosphate 5-phosphatase
- protein binding
- phosphatase domain
- proline rich domain
- NPXY motif
- Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
- phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
- phosphatase
- Src homology 2 (SH2) domain
- PR domain
- tyrosine phosphorylation site
Pathways
Biological processes and signaling networks where the Inpp5d gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- B Cell Receptor Signaling
- Fc Epsilon RI Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- FcγRIIB Signaling in B Lymphocytes
- FLT3 Signaling in Hematopoietic Progenitor Cells
- iCOS-iCOSL Signaling in T Helper Cells
- IL-10 Signaling
- IL-3 Signaling
- Insulin Receptor Signaling
- PDGF Signaling
- PI3K Signaling in B Lymphocytes
- PI3K/AKT Signaling
- PTEN Signaling
- Systemic Lupus Erythematosus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- Alzheimer disease
- thrombocytopenia
- chronic lymphocytic leukemia
- type M6 acute myeloid leukemia
- allergic rhinitis
- IgA nephropathy
- fibrosis
- runting
- bladder pain
phenotypes
- abnormal B cell differentiation
- abnormal B cell physiology
- abnormal CD4-positive alpha-beta T cell physiology
- abnormal CD8-positive alpha-beta T cell differentiation
- abnormal CD8-positive alpha-beta T cell physiology
- abnormal NK cell morphology
- abnormal T cell differentiation
- abnormal T cell physiology
- abnormal blood coagulation
- abnormal bone marrow cell physiology
- abnormal bone structure
- abnormal cell-mediated immunity
- abnormal definitive hematopoiesis
- abnormal eosinophil physiology
- abnormal erythropoiesis
- abnormal granulocyte differentiation
- abnormal ileum morphology
- abnormal interleukin level
- abnormal intestinal goblet cell morphology
- abnormal intestinal smooth muscle morphology
- abnormal intestine morphology
- abnormal leukocyte physiology
- abnormal long bone metaphysis morphology
- abnormal long bone morphology
- abnormal lung morphology
- abnormal lymphocyte cell number
- abnormal lymphocyte morphology
- abnormal lymphopoiesis
- abnormal macrophage chemotaxis
- abnormal monocyte differentiation
- abnormal mononuclear cell differentiation
- abnormal myelopoiesis
- abnormal neutrophil physiology
- abnormal osteoclast differentiation
- abnormal osteoclast morphology
- abnormal osteoclast physiology
- abnormal platelet activation
- abnormal pulmonary alveolus morphology
- abnormal skeleton morphology
- abnormal skeleton physiology
- abnormal trabecular bone morphology
- anemia
- cachexia
- decreased B cell number
- decreased CD4-positive alpha beta T cell number
- decreased CD8-positive alpha-beta T cell number
- decreased CD8-positive naive alpha-beta T cell number
- decreased NK cell number
- decreased alpha-beta T cell number
- decreased apoptosis
- decreased body size
- decreased body weight
- decreased bone marrow cell number
- decreased bone mineral density
- decreased bone strength
- decreased bone trabecula number
- decreased compact bone thickness
- decreased cytotoxic T cell cytolysis
- decreased heart rate
- decreased lymphocyte cell number
- decreased platelet aggregation
- decreased pre-B cell number
- decreased pro-B cell number
- decreased susceptibility to graft versus host disease
- decreased thymocyte number
- decreased trabecular bone thickness
- decreased trabecular bone volume
- enlarged lymph nodes
- enlarged spleen
- enlarged thymus
- ileum inflammation
- impaired natural killer cell mediated cytotoxicity
- increased B cell derived lymphoma incidence
- increased B-1 B cell number
- increased CD8-positive alpha-beta T cell number
- increased IgG2a level
- increased IgM level
- increased NK cell number
- increased bleeding time
- increased central memory CD8 positive alpha-beta T cell number
- increased circulating interleukin-6 level
- increased dendritic cell number
- increased effector memory CD4-positive alpha-beta T cell number
- increased effector memory CD8-positive alpha-beta T cell number
- increased immunoglobulin level
- increased interferon-beta secretion
- increased leukocyte cell number
- increased macrophage cell number
- increased mast cell degranulation
- increased monocyte cell number
- increased neutrophil cell number
- increased osteoclast cell number
- increased spleen weight
- increased tumor necrosis factor secretion
- intestinal inflammation
- lung hemorrhage
- lung inflammation
- postnatal growth retardation
- premature death
- pulmonary edema
- respiratory failure
- short femur
- small thymus
- spleen hyperplasia
- thrombocytopenia
role in cell
- cell death
- apoptosis
- size
- proliferation
- expression in
- motility
- growth
- adhesion
- phosphorylation in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cortical cytoskeleton
- Plasma Membrane
- membrane compartment
- actin filaments
- cytosol
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Inpp5d gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- determination of adult lifespan
- phosphatidylinositol biosynthetic process
- negative regulation of bone resorption
- positive regulation of erythrocyte differentiation
- negative regulation of neutrophil differentiation
- phosphate-containing compound metabolic process
- positive regulation of B cell differentiation
- negative regulation of monocyte differentiation
- phosphatidylinositol dephosphorylation
- negative regulation of interleukin-6 production
- negative regulation of signal transduction
- negative regulation of B cell proliferation
- positive regulation of apoptotic process
- immunoglobulin mediated immune response
- apoptotic process
- negative regulation of osteoclast differentiation
- negative regulation of immune response
- intracellular signal transduction
- T cell receptor signaling pathway
- regulation of immune response
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- membrane raft
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
- phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
- SH3 domain binding
- inositol-1,4,5-trisphosphate 5-phosphatase activity
- inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
- inositol-polyphosphate 5-phosphatase activity
- phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity