IL-17 Signaling
Interleukin 17 (IL-17), also referred to as IL-17A, is a member of a family of cytokines that includes IL-17B, -17C, -17D, -17E and -17F. IL-17 function is essential to a subset of CD4+ T-Cells called T helper 17 (Th17) cells. IL-17A is a pro-inflammatory cytokine primarily secreted by T lymphocytes. It promotes expansion and recruitment of innate immune cells such as neutrophils and stimulates production of beta-defensins and other anti-microbial peptides....
Pathway Summary
Interleukin 17 (IL-17), also referred to as IL-17A, is a member of a family of cytokines that includes IL-17B, -17C, -17D, -17E and -17F. IL-17 function is essential to a subset of CD4+ T-Cells called T helper 17 (Th17) cells. IL-17A is a pro-inflammatory cytokine primarily secreted by T lymphocytes. It promotes expansion and recruitment of innate immune cells such as neutrophils and stimulates production of beta-defensins and other anti-microbial peptides.IL-17 binds to and signals through a transmembrane, heterotrimeric receptor complex that consists of IL-17 receptor A (IL-17RA), IL-17 receptor B (IL-17RB) and IL-17 receptor C (IL-17RC). IL-17A activates NF-kappaB and MAPK pathways via adapter molecules TRAF6 and ActI. Other signaling pathways like the Ras/ERK and the JAK/PI3K/AKT are also activated leading to the induction of pro-inflammatory cytokines, chemokines, matrix metalloproteinases and anti-microbial peptides. Thus, IL-17 is a unique cytokine that plays a central role in integrating adaptive and innate immune responses.
IL-17 Signaling Genes list
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AKT1AKT serine/threonine kinase 1 AKT2AKT serine/threonine kinase 2 AKT3AKT serine/threonine kinase 3 ATF2activating transcription factor 2 CCL11C-C motif chemokine ligand 11 CCL17C-C motif chemokine ligand 17 CCL2C-C motif chemokine ligand 2 CCL20C-C motif chemokine ligand 20 CCL22C-C motif chemokine ligand 22 CD40LGCD40 ligand CD70CD70 molecule CEBPBCCAAT enhancer binding protein beta CLCF1cardiotrophin like cytokine factor 1 CNTFciliary neurotrophic factor CSF2colony stimulating factor 2 CSF3colony stimulating factor 3 CXCL1C-X-C motif chemokine ligand 1 CXCL2C-X-C motif chemokine ligand 2 CXCL5C-X-C motif chemokine ligand 5 CXCL8C-X-C motif chemokine ligand 8 DEFB1defensin beta 1 DEFB108Bdefensin beta 108B DEFB110defensin beta 110 DEFB112defensin beta 112 DEFB113defensin beta 113 DEFB114defensin beta 114 DEFB115defensin beta 115 DEFB116defensin beta 116 DEFB118defensin beta 118 DEFB119defensin beta 119 DEFB123defensin beta 123 DEFB124defensin beta 124 DEFB125defensin beta 125 DEFB126defensin beta 126 DEFB127defensin beta 127 DEFB128defensin beta 128 DEFB129defensin beta 129 DEFB132defensin beta 132 EDAectodysplasin A ELK1ETS transcription factor ELK1 ERASES cell expressed Ras FASLGFas ligand FOSFos proto-oncogene, AP-1 transcription factor subunit GSK3Bglycogen synthase kinase 3 beta HRASHRas proto-oncogene, GTPase HSP90AA1heat shock protein 90 alpha family class A member 1 HSP90AB1heat shock protein 90 alpha family class B member 1 HSP90B1heat shock protein 90 beta family member 1 IFNGinterferon gamma IL11interleukin 11 IL12Ainterleukin 12A IL12Binterleukin 12B IL13interleukin 13 IL15interleukin 15 IL17Ainterleukin 17A IL17Binterleukin 17B IL17Cinterleukin 17C IL17Dinterleukin 17D IL17Finterleukin 17F IL17RAinterleukin 17 receptor A IL17RBinterleukin 17 receptor B IL17RCinterleukin 17 receptor C IL17REinterleukin 17 receptor E IL18interleukin 18 IL1Ainterleukin 1 alpha IL1Binterleukin 1 beta IL1F10interleukin 1 family member 10 IL2interleukin 2 IL21interleukin 21 IL25interleukin 25 IL3interleukin 3 IL31interleukin 31 IL33interleukin 33 IL36Ainterleukin 36 alpha IL36Binterleukin 36 beta IL36Ginterleukin 36 gamma IL37interleukin 37 IL4interleukin 4 IL5interleukin 5 IL6interleukin 6 JAK1Janus kinase 1 JAK2Janus kinase 2 JUNJun proto-oncogene, AP-1 transcription factor subunit KRASKRAS proto-oncogene, GTPase LCN2lipocalin 2 LEPleptin LIFLIF interleukin 6 family cytokine LTAlymphotoxin alpha LTBlymphotoxin beta MAP2K3mitogen-activated protein kinase kinase 3 MAP2K4mitogen-activated protein kinase kinase 4 MAP2K6mitogen-activated protein kinase kinase 6 MAP3K14mitogen-activated protein kinase kinase kinase 14 MAP3K7mitogen-activated protein kinase kinase kinase 7 MAPK1mitogen-activated protein kinase 1 MAPK10mitogen-activated protein kinase 10 MAPK11mitogen-activated protein kinase 11 MAPK12mitogen-activated protein kinase 12 MAPK13mitogen-activated protein kinase 13 MAPK14mitogen-activated protein kinase 14 MAPK3mitogen-activated protein kinase 3 MAPK8mitogen-activated protein kinase 8 MAPK9mitogen-activated protein kinase 9 MIR23BmicroRNA 23b MMP13matrix metallopeptidase 13 MMP2matrix metallopeptidase 2 MMP3matrix metallopeptidase 3 MMP9matrix metallopeptidase 9 MRASmuscle RAS oncogene homolog MUC5ACmucin 5AC, oligomeric mucus/gel-forming MUC5Bmucin 5B, oligomeric mucus/gel-forming NFKB1nuclear factor kappa B subunit 1 NOS2nitric oxide synthase 2 NRASNRAS proto-oncogene, GTPase OSMoncostatin M PDGFCplatelet derived growth factor C PGFplacental growth factor PIK3C2Aphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha PIK3C2Bphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta PIK3C2Gphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma PIK3C3phosphatidylinositol 3-kinase catalytic subunit type 3 PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PIK3CBphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta PIK3CDphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta PIK3CGphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma PIK3R1phosphoinositide-3-kinase regulatory subunit 1 PIK3R2phosphoinositide-3-kinase regulatory subunit 2 PIK3R3phosphoinositide-3-kinase regulatory subunit 3 PIK3R4phosphoinositide-3-kinase regulatory subunit 4 PIK3R5phosphoinositide-3-kinase regulatory subunit 5 PIK3R6phosphoinositide-3-kinase regulatory subunit 6 PROK1prokineticin 1 PTGS2prostaglandin-endoperoxide synthase 2 RALARAS like proto-oncogene A RALBRAS like proto-oncogene B RAP1ARAP1A, member of RAS oncogene family RAP1BRAP1B, member of RAS oncogene family RAP2ARAP2A, member of RAS oncogene family RAP2BRAP2B, member of RAS oncogene family RASD1ras related dexamethasone induced 1 RASD2RASD family member 2 RELARELA proto-oncogene, NF-kB subunit RGS13regulator of G protein signaling 13 RGS16regulator of G protein signaling 16 RRASRAS related RRAS2RAS related 2 SRSF1serine and arginine rich splicing factor 1 TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2 TGFB1transforming growth factor beta 1 TGFB2transforming growth factor beta 2 TGFB3transforming growth factor beta 3 TNFtumor necrosis factor TNFRSF11BTNF receptor superfamily member 11b TNFSF10TNF superfamily member 10 TNFSF11TNF superfamily member 11 TNFSF12TNF superfamily member 12 TNFSF13TNF superfamily member 13 TNFSF13BTNF superfamily member 13b TNFSF14TNF superfamily member 14 TNFSF15TNF superfamily member 15 TNFSF4TNF superfamily member 4 TNFSF8TNF superfamily member 8 TNFSF9TNF superfamily member 9 TRAF2TNF receptor associated factor 2 TRAF3IP2TRAF3 interacting protein 2 TRAF5TNF receptor associated factor 5 TRAF6TNF receptor associated factor 6 VEGFAvascular endothelial growth factor A VEGFBvascular endothelial growth factor B VEGFCvascular endothelial growth factor C VEGFDvascular endothelial growth factor D
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