icon_0328_cc_gen_hmr_bacteria-s

Parkinson's Signaling

Parkinson's disease (PD) is a neurodegenerative disorder associated with loss of dopaminergic neurons and the presence of intracytoplasmic-ubiquitinated inclusions (Lewy bodies) and neurites. Several genes are implicated in PD including alpha-synuclein, parkin, ubiquitin C-terminal hydrolase L1 (UCHL1) and PARK-3, -4 and -7....

Parkinson's Signaling

Pathway Summary

Parkinson's disease (PD) is a neurodegenerative disorder associated with loss of dopaminergic neurons and the presence of intracytoplasmic-ubiquitinated inclusions (Lewy bodies) and neurites. Several genes are implicated in PD including alpha-synuclein, parkin, ubiquitin C-terminal hydrolase L1 (UCHL1) and PARK-3, -4 and -7.A major pathway that leads to PD involves aberrations in the ubiquitin-proteasome pathway. Some of the proteins involved: 1) Parkin - an E3-ubiquitin-protein ligase that ubiquitinates several proteins and targets them for proteasomal degradation, 2) Alpha-synuclein - abnormal aggreation of this protein is often seen in PD, 3) UCHL1 - mutations in this thiol protease could lead to aberrations in the proteolytic pathway and aggregation of proteins, 4) Parkin associated endothelin-like receptor (Pael-R), 5) Septin 5, 6) Synphilin-1.

Products related to Parkinson's Signaling

Explore products related to Parkinson's Signaling
GeneGlobe ID: PAHS-012Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Apoptosis
RT2 Profiler PCR Array
Product Specification
GeneGlobe ID: PAHS-158Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Dopamine & Serotonin Pathway
RT2 Profiler PCR Array
Product Specification
GeneGlobe ID: PAHS-124Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Parkinson's Disease
RT2 Profiler PCR Array
Product Specification
GeneGlobe ID: SBHS-158Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Dopamine & Serotonin Pathway
QuantiNova LNA PCR Focus Panel
Product Specification
GeneGlobe ID: SBHS-124Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Parkinson's Disease
QuantiNova LNA PCR Focus Panel
Product Specification
GeneGlobe ID: UPHS-012Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Apoptosis
QuantiNova LNA Probe PCR Focus Panel
Product Specification
GeneGlobe ID: SBHS-012Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Apoptosis
QuantiNova LNA PCR Focus Panel
Product Specification
GeneGlobe ID: UPHS-158Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Dopamine & Serotonin Pathway
QuantiNova LNA Probe PCR Focus Panel
Product Specification
GeneGlobe ID: UPHS-124Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Parkinson's Disease
QuantiNova LNA Probe PCR Focus Panel
Product Specification

Didn't find what you're looking for?

Discover other products relevant to this gene list with our Panel Finder. Check it out.