Cyb561 Gene Summary [Mouse]
Enables transmembrane monodehydroascorbate reductase activity. Involved in ascorbate homeostasis and intracellular iron ion homeostasis. Located in chromaffin granule membrane. Is expressed in several structures, including genitourinary system; gut; nervous system; node; and nose. Orthologous to human CYB561 (cytochrome b561). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyb561 |
| Official Name | cytochrome b-561 [Source:MGI Symbol;Acc:MGI:103253] |
| Ensembl ID | ENSMUSG00000019590 |
| Bio databases IDs | |
| Aliases | cytochrome b-561 |
| Synonyms | CGCytb, CYB561A1, Cytochrome b-561, FRRS2, ORTHYP2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cyb561 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- oxidoreductase
- Cytochrome_b_N
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- NFkB (complex)
- MACROH2A1
- iron ion
disease
- neoplasia
- breast cancer
- organismal death
- orthostatic hypotension type 2
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- juvenile dermatomyositis
- autosomal dominant Emery-Dreifuss muscular dystrophy
- Duchenne muscular dystrophy
- ductal breast carcinoma
- ductal breast cancer
phenotypes
- abnormal bone mineralization
- abnormal bone structure
- abnormal cranium morphology
- abnormal gait
- abnormal head size
- abnormal iris morphology
- abnormal maxilla morphology
- abnormal placement of pupils
- abnormal response to new environment
- abnormal retinal blood vessel morphology
- abnormal snout morphology
- abnormal tail length
- decreased bone mineral content
- decreased circulating calcium level
- decreased circulating chloride level
- decreased circulating serum albumin level
- decreased circulating total protein level
- decreased exploration in new environment
- decreased fasting circulating glucose level
- enlarged heart
- hypoactivity
- improved glucose tolerance
- increased bone mineral content
- increased circulating alkaline phosphatase level
- increased circulating amylase level
- increased circulating triglyceride level
- increased total body fat amount
- narrow eye opening
- thrombocytosis
- tremors
- abnormal behavior
- abnormal circulating alkaline phosphatase level
- abnormal circulating amylase level
- abnormal circulating triglyceride level
- abnormal coat/hair pigmentation
- abnormal exploration in a new environment
- abnormal fasting circulating glucose level
- abnormal respiratory quotient
- decreased circulating LDL cholesterol level
- increased circulating fructosamine level
- increased circulating iron level
- increased circulating magnesium level
- increased erythrocyte cell number
- increased hematocrit
- increased hemoglobin content
role in cell
- expression in
- proliferation
- ubiquitination in
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- secretory granule membrane
- dense-core vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cyb561 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular iron ion homeostasis
- electron transport chain
Cellular Component
Where in the cell the gene product is active
- membrane
- chromaffin granule membrane
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- oxidoreductase activity
- metal ion binding