Lcn2 Gene Summary [Mouse]
Enables iron ion binding activity. Involved in innate immune response; positive regulation of cold-induced thermogenesis; and siderophore transport. Acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand; response to bacterium; and response to virus. Located in extracellular space. Is expressed in several structures, including genitourinary system; gut; liver; lung; and spleen. Human ortholog(s) of this gene implicated in intrahepatic cholangiocarcinoma and urinary tract infection. Orthologous to human LCN2 (lipocalin 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Lcn2 |
| Official Name | lipocalin 2 [Source:MGI Symbol;Acc:MGI:96757] |
| Ensembl ID | ENSMUSG00000026822 |
| Bio databases IDs | |
| Aliases | lipocalin 2 |
| Synonyms | 24p3, Alpha2u globulin related, AW212229, HNL, LIPOCALIN 2, MSFI, NEUTROPHIL LIPOCALIN, NGAL, NRL, p25, SIDEROCALIN, Sip24, Uterocalin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lcn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- lipocalin/cytosolic fatty acid-binding protein family
- protease binding
- macrolide binding
- iron ion binding
- protein binding
- identical protein binding
- Lipocalin / cytosolic fatty-acid binding protein family
- transporter
Pathways
Biological processes and signaling networks where the Lcn2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dextran sodium sulfate-induced colitis
- neoplasia
- epithelial neoplasia
- epithelial cancer
- cancer
- urogenital cancer
- metastasis
- papillomatosis
- squamous cell cancer
- hyperplasia
phenotypes
- decreased total body fat amount
- increased bone mineral content
- increased bone mineral density
- increased heart weight
- increased urine microalbumin level
- abnormal erythropoiesis
- abnormal mast cell physiology
- abnormal myelopoiesis
- decreased apoptosis
- decreased circulating adiponectin level
- decreased physiological sensitivity to xenobiotic
- decreased thymocyte apoptosis
- hepatic steatosis
- impaired adaptive thermogenesis
- impaired glucose tolerance
- increased B cell number
- increased bone marrow cell number
- increased brown adipose tissue amount
- increased circulating LDL cholesterol level
- increased circulating cholesterol level
- increased circulating insulin level
- increased erythroblast number
- increased erythrocyte cell number
- increased erythroid progenitor cell number
- increased fasting circulating glucose level
- increased fat cell size
- increased hematocrit
- increased kidney weight
- increased leukocyte cell number
- increased liver triglyceride level
- increased liver weight
- increased lymphocyte cell number
- increased macrophage cell number
- increased mean corpuscular hemoglobin
- increased monocyte cell number
- increased neutrophil cell number
- increased sensitivity to induced morbidity/mortality
- increased spleen weight
- increased splenocyte number
- increased susceptibility to bacterial infection
- increased susceptibility to diet-induced obesity
- increased white adipose tissue amount
- insulin resistance
- myeloid hyperplasia
- reduced female fertility
- sepsis
- spleen hyperplasia
- thrombocytopenia
- thymus hyperplasia
role in cell
- cell viability
- expression in
- activation
- production in
- apoptosis
- proliferation
- cellular infiltration by
- colony formation by
- migration
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granule lumen
- Plasma Membrane
- Endoplasmic Reticulum
- granules
- cytosol
- apical cell surfaces
- peri-Golgi vesicles
- specific granules
- extracellular matrix
- brush border
- plasma
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lcn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- siderophore transport
- innate immune response
- apoptotic process
- defense response to bacterium
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- specific granule lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- iron ion binding