NEU3 Gene Summary [Human]
This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | NEU3 |
| Official Name | neuraminidase 3 [Source:HGNC Symbol;Acc:HGNC:7760] |
| Ensembl ID | ENSG00000162139 |
| Bio databases IDs | |
| Aliases | neuraminidase 3 |
| Synonyms | Membrane sialidase, neuraminidase 3, Pmgs, SIAL3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NEU3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha-sialidase
- sialidases/neuraminidases
- Exo-alpha-sialidase
- enzyme
- protein binding
- BNR repeat-like domain
- caveolin binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal neoplasia
- gastrointestinal neoplasia
- ataxia
- obesity
- neurodegeneration
- hyperplasia
- weight loss
- hyperinsulinism
role in cell
- proliferation
- growth
- expression in
- production in
- apoptosis
- autophagy by
- activation in
- adhesion
- number
- mass
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- intracellular space
- cellular membrane
- Nucleus
- lysosome
- cytosol
- plasma membrane extracellular face
- microdomains
- lysosome membrane
- endosomal membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NEU3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- negative regulation of clathrin-mediated endocytosis
- glycosphingolipid catabolic process
- positive regulation of epidermal growth factor receptor signaling pathway
- oligosaccharide catabolic process
- ganglioside catabolic process
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- caveola
- cytoplasm
- membrane
- external side of plasma membrane
- recycling endosome membrane
- lysosomal membrane
- plasma membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- alpha-sialidase activity
- exo-alpha-(2->6)-sialidase activity
- protein binding
- exo-alpha-(2->8)-sialidase activity
- exo-alpha-sialidase activity
- exo-alpha-(2->3)-sialidase activity